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Journal of Obesity
Volume 2014, Article ID 185349, 4 pages
http://dx.doi.org/10.1155/2014/185349
Research Article

A Preliminary Observation of Weight Loss Following Left Gastric Artery Embolization in Humans

1Department of Imaging, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, FND 216, Boston, MA 02114, USA
2Division of Interventional Radiology, Department of Imaging, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, 290 Gray/Bigelow, Boston, MA 02114, USA

Received 6 June 2014; Revised 1 September 2014; Accepted 17 September 2014; Published 30 September 2014

Academic Editor: Aron Weller

Copyright © 2014 Andrew J. Gunn and Rahmi Oklu. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background/Objectives. Embolization of the left gastric artery (LGA), which preferentially supplies the gastric fundus, has been shown to produce weight loss in animal models. However, weight loss after LGA embolization in humans has not been previously established. The aim of this study was to evaluate postprocedural weight loss in patients following LGA embolization. Subjects/Methods. A retrospective analysis of the medical records of patients who underwent LGA embolization for upper gastrointestinal (GI) bleeding was performed. Postprocedural weight loss in this group was compared to a control group of patients who had undergone embolization of other arteries for upper GI bleeding. Results. The experimental group () lost an average of 7.3% of their initial body weight within three months of LGA embolization, which was significantly greater than the 2% weight loss observed in the control group () (). No significant differences were seen between the groups in preprocedural body mass index (BMI), age, postprocedural care in the intensive care unit, history of malignancy, serum creatinine, or left ventricular ejection fraction. Conclusions. The current data suggest that body weight in humans may be modulated via LGA embolization. Continued research is warranted with prospective studies to further investigate this phenomenon.