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Journal of Obesity
Volume 2014 (2014), Article ID 690123, 7 pages
Research Article

Effects of Obesity on Bone Mass and Quality in Ovariectomized Female Zucker Rats

1Department of Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, FL 32306, USA
2The Center for Advancing Exercise and Nutrition Research on Aging (CAENRA), Florida State University, Tallahassee, FL 32306, USA
3Department of Kinesiology and Health Promotion, California State Polytechnic University, Pomona, CA 91768, USA
4Department of Dietetics and Nutrition, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
5Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
6Arkansas Children’s Hospital Research Institute, Little Rock, AR 72202, USA
7Arkansas Cancer Research Center, Little Rock, AR 72205, USA

Received 15 May 2014; Revised 27 August 2014; Accepted 3 September 2014; Published 18 September 2014

Academic Editor: Andras Hajnal

Copyright © 2014 Rafaela G. Feresin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Obesity and osteoporosis are two chronic conditions that have been increasing in prevalence. Despite prior data supporting the positive relationship between body weight and bone mineral density (BMD), recent findings show excess body weight to be detrimental to bone mass, strength, and quality. To evaluate whether obesity would further exacerbate the effects of ovariectomy on bone, we examined the tibiae and fourth lumbar (L4) vertebrae from leptin receptor-deficient female () Zucker rats and their heterozygous lean controls () that were either sham-operated or ovariectomized (Ovx). BMD of L4 vertebra was measured using dual-energy X-ray absorptiometry, and microcomputed tomography was used to assess the microstructural properties of the tibiae. Ovariectomy significantly () decreased the BMD of L4 vertebrae in lean and obese Zucker rats. Lower trabecular number and greater trabecular separation () were also observed in the tibiae of lean- and obese-Ovx rats when compared to sham rats. However, only the obese-Ovx rats had lower trabecular thickness (Tb.Th) () than the other groups. These findings demonstrated that ovarian hormone deficiency adversely affected bone mass and quality in lean and obese rats while obesity only affected Tb.Th in Ovx-female Zucker rats.