Genetic and Diet-Induced Obesity Increased Intestinal Tumorigenesis in the Double Mutant Mouse Model Multiple Intestinal Neoplasia X Obese via Disturbed Glucose Regulation and Inflammation

Figure 2

Number of small intestinal tumors. The number of small intestinal tumors (mean ± SD) is shown for (a) female and (b) male Apc^Min/+ mice with the three ob genotypes, terminated at 11 weeks of age. The mice were exposed to 0.9% NaCl and given a 10% fat diet (white columns) or 0.9% NaCl and a 45% fat diet (light grey columns), or they were exposed to PhIP and given a 10% fat diet (dark grey columns) or PhIP and a 45% fat diet (black columns). –17 mice.

(a)

(b)