Genetic and Diet-Induced Obesity Increased Intestinal Tumorigenesis in the Double Mutant Mouse Model Multiple Intestinal Neoplasia X Obese via Disturbed Glucose Regulation and Inflammation

Figure 4

Localization of tumors along the small intestine and colon. This is shown for pooled female and male Apc^Min/+ X Lep^ob/ob mice (○), Apc^Min/+ X Lep^ob/wt (∆) and Apc^Min/+ X Lep^wt/wt mice (□) on a 10% fat diet (open symbols) or a 45% fat diet (filled symbols) treated with (a) 0.9% NaCl or (b) PhIP. The tumor position is given as distance from the stomach measured in cm. Mean number of tumors/cm intestine for the mice in each experimental group was scored. –17 mice.

(a)

(b)