Genetic and Diet-Induced Obesity Increased Intestinal Tumorigenesis in the Double Mutant Mouse Model Multiple Intestinal Neoplasia X Obese via Disturbed Glucose Regulation and Inflammation

Figure 5

Blood glucose levels as area under the curve (AUC) from a glucose tolerance test (GTT). The GTT was performed on mice fasted for 6 h at 6 weeks of age. Blood glucose was measured 5 min before and 15, 30, 60 and 120 min after an i.p. injection of 2 g/kg bw glucose. The data were pooled for Apc^Min/+ and Apc^+/+ mice. The mice were treated with either 0.9% NaCl, (a) females and (b) males, or with PhIP, (c) females and (d) males. The mice had ob genotype ob/ob (○), ob/wt (∆) or wt/wt (□) and were given a 10% fat diet (open symbols) or a 45% fat diet (filled symbols). –9 mice.

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