Genetic and Diet-Induced Obesity Increased Intestinal Tumorigenesis in the Double Mutant Mouse Model Multiple Intestinal Neoplasia X Obese via Disturbed Glucose Regulation and Inflammation

Figure 7

Survival of mice. Untreated pooled female and male Apc^Min/+ and Apc^+/+ mice of all three ob genotypes were kept under regular observation until euthanized. Survival of each genotype of mice was depicted as decreasing % of surviving mice compared with the number of mice present at the start of the experiment (, 30 and 31 for groups of Apc^Min/+ X Lep^ob/ob (○), Apc^Min/+ X Lep^ob/wt (∆) and Apc^Min/+ X Lep^wt/wt (□) mice, respectively, and , 28 and 24 for Apc^+/+ X Lep^ob/ob (●), Apc^+/+ X Lep^ob/wt (▲) and Apc^+/+ X Lep^wt/wt (■) mice, respectively.