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Journal of Obesity
Volume 2015, Article ID 473430, 10 pages
Review Article

The Molecular Mechanism Underlying Continuous Exercise Training-Induced Adaptive Changes of Lipolysis in White Adipose Cells

1Department of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine, Mitaka, Tokyo 181-8611, Japan
2Graduate School of Health and Sports Science, Doshisha University, Kyotanabe, Kyoto 610-0394, Japan
3Faculty of Culture and Sport Policy, Toin University of Yokohama, Yokohama, Kanagawa 225-8503, Japan
4Department of Third Internal Medicine, Kyorin University, School of Medicine, Mitaka, Tokyo 181-8611, Japan

Received 6 February 2015; Revised 4 April 2015; Accepted 27 April 2015

Academic Editor: Eric Doucet

Copyright © 2015 Junetsu Ogasawara et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Physical exercise accelerates the mobilization of free fatty acids from white adipocytes to provide fuel for energy. This happens in several tissues and helps to regulate a whole-body state of metabolism. Under these conditions, the hydrolysis of triacylglycerol (TG) that is found in white adipocytes is known to be augmented via the activation of these lipolytic events, which is referred to as the “lipolytic cascade.” Indeed, evidence has shown that the lipolytic responses in white adipocytes are upregulated by continuous exercise training (ET) through the adaptive changes in molecules that constitute the lipolytic cascade. During the past few decades, many lipolysis-related molecules have been identified. Of note, the discovery of a new lipase, known as adipose triglyceride lipase, has redefined the existing concepts of the hormone-sensitive lipase-dependent hydrolysis of TG in white adipocytes. This review outlines the alterations in the lipolytic molecules of white adipocytes that result from ET, which includes the molecular regulation of TG lipases through the lipolytic cascade.