The Intrauterine and Nursing Period Is a Window of Susceptibility for Development of Obesity and Intestinal Tumorigenesis by a High Fat Diet in Min/+ Mice as Adults

Figure 9

The number of small intestinal tumors for pooled male and female Min/+ mice (mean ± SD). Two separate experimental groups receiving a 45% fat diet during in utero and nursing period or throughout life were injected with PhIP (marked P). The experimental groups are as explained in the legend to Figure 1. . ignificantly different from the negative control group given a 10% fat diet throughout life. ignificantly different from the group given a 45% fat diet throughout life. ignificantly different from the group given a 45% fat diet in utero and during nursing. ignificantly different with PhIP compared with no PhIP exposure in the groups given a 45% fat diet during in utero and nursing period. ignificantly different with PhIP compared with no PhIP exposure in the groups given a 45% fat diet throughout life. n.s. = not significantly different.