The Influence of Urinary Concentrations of Organophosphate Metabolites on the Relationship between BMI and Cardiometabolic Health Risk
Table 1
(a) Participant characteristics for those above and below the detection limit for dimethyl metabolites. (b) Participant characteristics for those above and below the detection limit for diethyl metabolites.
(a)
DMP
DMTP
DMDTP
Below ( = 1299)
Above ( = 928)
value
Below ( = 740)
Above ( = 1487)
value
Below ( = 1636)
Above ( = 591)
value
Age (years)
43.5 ± 0.5
45.4 ± 0.6
<0.01
42.5 ± 0.7
45.3 ± 0.5
<0.0001
43.7 ± 0.4
45.8 ± 0.7
<0.01
Sex, (% male)
704 (54.2)
452 (48.7)
0.04
386 (52.2)
770 (51.8)
0.25
872 (53.3)
284 (48.1)
0.03
BMI (kg/m2)
28.1 ± 0.2
27.9 ± 0.3
0.44
27.6 ± 0.2
28.2 ± 0.2
0.01
28.0 ± 0.2
28.0 ± 0.3
0.90
Metabolic variables
HOMA-IR
2.92 ± 0.09
2.74 ± 0.09
0.10
2.68 ± 0.10
2.93 ± 0.08
0.03
2.84 ± 0.08
2.84 ± 0.12
0.98
Insulin (pmol/L)
67.4 ± 1.9
64.2 ± 1.8
0.15
63.9 ± 2.0
67.2 ± 1.7
0.16
65.8 ± 1.5
66.7 ± 2.8
0.71
HbA1c (%)
5.4 ± 0.1
5.4 ± 0.1
0.86
5.4 ± 0.1
5.5 ± 0.1
0.03
5.4 ± 0.1
5.5 ± 0.1
0.33
Glucose (mmol/L)
5.60 ± 0.04
5.58 ± 0.04
0.68
5.51 ± 0.05
5.63 ± 0.04
0.04
5.59 ± 0.03
5.58 ± 0.06
0.79
HDL (mmol/L)
1.35 ± 0.01
1.37 ± 0.02
0.33
1.33 ± 0.02
1.37 ± 0.02
0.03
1.35 ± 0.01
1.37 ± 0.02
0.39
LDL (mmol/L)
3.11 ± 0.03
3.07 ± 0.03
0.31
3.21 ± 0.04
3.03 ± 0.03
<0.0001
3.11 ± 0.03
3.06 ± 0.05
0.30
Total cholesterol (mmol/L)
5.13 ± 0.04
5.11 ± 0.04
0.65
5.21 ± 0.04
5.07 ± 0.03
<0.01
5.12 ± 0.03
5.13 ± 0.06
0.85
Triglyceride (mmol/L)
1.47 ± 0.03
1.47 ± 0.03
0.56
1.45 ± 0.04
1.47 ± 0.02
0.56
1.44 ± 0.02
1.52 ± 0.04
0.03
CRP (nmol/L)
34.3 ± 1.9
37.1 ± 2.9
0.15
34.3 ± 2.9
36.2 ± 1.0
0.48
35.2 ± 1.9
35.2 ± 2.9
0.85
SBP (mmHg)
120 ± 1
120 ± 1
0.93
119 ± 1
121 ± 1
0.06
120 ± 1
120 ± 1
0.93
DBP (mmHg)
71 ± 1
72 ± 1
<0.01
72 ± 1
72 ± 1
0.87
71 ± 1
72 ± 1
0.29
DMP = dimethylphosphate, DMTP = dimethyldiphosphate, and DMDTP = dimethyldithiophosphate. Values are presented as mean ± SE. values represent the statistical difference between detection statuses.
(b)
DEP
DETP
DEDTP
Below ( = 1282)
Above ( = 945)
value
Below ( = 1376)
Above ( = 851)
value
Below ( = 2109)
Above ( = 118)
value
Age (years)
43.6 ± 0.6
45.1 ± 0.6
0.02
44.7 ± 0.4
43.6 ± 0.6
0.11
44.5 ± 0.4
40.6 ± 1.4
<0.01
Sex (% male)
693 (54.1)
463 (49.0)
0.05
701 (50.9)
455 (53.4)
0.10
1098 (52.1)
58 (49.2)
0.30
BMI (kg/m2)
28.0 ± 0.2
27.9 ± 0.2
0.53
28.2 ± 0.2
27.7 ± 0.2
0.06
28.0 ± 0.2
27.6 ± 0.6
0.42
Metabolic variables
HOMA-IR
2.82 ± 0.09
2.87 ± 0.13
0.63
2.90 ± 0.09
2.74 ± 0.09
0.17
2.85 ± 0.07
2.80 ± 0.21
0.86
Insulin (pmol/L)
65.5 ± 2.0
66.7 ± 2.6
0.60
67.2 ± 1.7
64.1 ± 1.8
0.19
66.0 ± 1.4
67.2 ± 4.7
0.79
HbA1c (%)
5.4 ± 0.1
5.4 ± 0.1
0.55
5.5 ± 0.1
5.4 ± 0.1
0.10
5.4 ± 0.1
5.3 ± 0.1
0.01
Glucose (mmol/L)
5.59 ± 0.05
5.59 ± 0.04
0.95
5.61 ± 0.04
5.56 ± 0.04
0.40
5.60 ± 0.03
5.40 ± 0.07
0.09
HDL (mmol/L)
1.35 ± 0.02
1.37 ± 0.02
0.22
1.36 ± 0.01
1.35 ± 0.02
0.57
1.36 ± 0.01
1.28 ± 0.04
0.02
LDL (mmol/L)
3.08 ± 0.03
3.12 ± 0.04
0.35
3.12 ± 0.03
3.05 ± 0.04
0.08
3.10 ± 0.02
3.05 ± 0.11
0.55
Total cholesterol (mmol/L)
5.09 ± 0.03
5.17 ± 0.04
0.07
5.15 ± 0.03
5.07 ± 0.04
0.09
5.13 ± 0.03
4.98 ± 0.15
0.11
Triglyceride (mmol/L)
1.44 ± 0.03
1.50 ± 0.03
0.07
1.46 ± 0.02
1.46 ± 0.03
0.97
1.47 ± 0.02
1.43 ± 0.10
0.65
CRP (nmol/L)
34.3 ± 1.0
36.2 ± 2.9
0.37
37.1 ± 1.9
32.4 ± 1.9
0.03
35.2 ± 1.0
35.2 ± 7.6
0.99
SBP (mmHg)
120 ± 1
121 ± 1
0.08
121 ± 1
119 ± 1
0.07
120 ± 1
119 ± 2
0.38
DBP (mmHg)
71 ± 1
72 ± 1
<0.01
72 ± 1
72 ± 1
0.90
71 ± 1
73 ± 1
0.04
DEP = diethylphosphate, DETP = diethyldiphosphate, and DEDTP = diethyldithiophosphate. Values are presented as mean ± SE. values represent the statistical difference between detection statuses.
