Review Article
Bile Acids, FXR, and Metabolic Effects of Bariatric Surgery
Figure 2
Mechanism of bile acid gene regulation. Bile acids can bind to the farnesoid X receptor (FXR) transcription factor which can regulate gene expression through binding to specific DNA motifs and can heterodimerize with retinoic X receptor-α (RXR-α) to regulate the expression of target genes.