Research Article
Altered Left Ventricular Ion Channel Transcriptome in a High-Fat-Fed Rat Model of Obesity: Insight into Obesity-Induced Arrhythmogenesis
Table 2
Simulated changes in current density based on the mRNA expression differences shown in Figures
1–
3.
| Channel | Current | High fat |
| 1.5 | | +163.60% | 1.2 | | +441.28% | 1.4, 4.2, and 4.3 | | +240.45% | 1.5 | | +232.73% | HCN4 | | +222% | 2.1 | | +233.83% | NCX1 | | +290.10% | SERCA2a | SR Ca2+ uptake | +139% | RYR2 | SR Ca2+ release | +253.97% | ATP1α1-3 | | 251% |
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