Journal of Obesity / 2016 / Article / Tab 2

Clinical Study

The Effect of Eighteen-Month Metformin Treatment in Obese Adolescents: Comparison of Results Obtained in Daily Practice with Results from a Clinical Trial

Table 2

Results after 18 months of treatment.

Daily clinical practice group () RCT group ()Delta
value

BMI (kg/m2)31.0 (27.9–32.8)30.5 (26.0–32.4)−0.36 (−2.10–1.58)29.8 (28.1–34.5)29.9 (26.3–33.6)0.22 (−2.87–1.27)0.686
BMI-SDS3.23 (3.05–3.64)3.00 (2.43–3.37)−0.15 (−0.54–0.05)3.10 (2.72–3.52)2.90 (2.34–3.39)−0.12 (−0.50–0.08)0.990
FPG (mmol/l)5.0 (4.8–5.6)5.4 (5.0–5.7)a0.2 (0.0–0.3)a4.8 (4.7–5.0)4.6 (4.4–4.8)−0.2 (−0.5–0.0)0.001
FPI (μU/ml)31.0 (21.0–41.9)19.6 (11.0–34.0)a−5.0 (−20.5–6.3)a18.0 (11.0–27.0)15.0 (10.0–20.0)−3.0 (−13.0–6.0)0.661
HOMA-IR7.16 (4.31–8.96)4.29 (2.52–9.43)a−1.03 (−4.48–1.88)a4.00 (2.30–6.36)3.00 (2.00–4.29)−1.00 (−3.17–1.47)0.802
HbA1c34 (32–39)a34 (33–36)a−1.0 (−3.5–3.5)b33 (31–34)34 (31–34)c1.0 (−1.0–2.3)c0.480

Data are presented as median (interquartile range). ; ; .
BMI (SDS): body mass index (standard deviation score); FPG: fasted plasma glucose; FPI: fasted plasma insulin; HOMA-IR: homeostasis model assessment for insulin resistance.

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