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Journal of Obesity
Volume 2016 (2016), Article ID 8375828, 5 pages
http://dx.doi.org/10.1155/2016/8375828
Research Article

Leptin, Leptin Soluble Receptor, and the Free Leptin Index following a Diet and Physical Activity Lifestyle Intervention in Obese Males and Females

Department of Rehabilitation Science, George Mason University, 4400 University Drive, MS 2G7, Fairfax, VA 22030, USA

Received 19 July 2016; Revised 17 October 2016; Accepted 20 October 2016

Academic Editor: R. Prager

Copyright © 2016 Jeffrey E. Herrick et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. L. Chan, K. Heist, A. M. DePaoli, J. D. Veldhuis, and C. S. Mantzoros, “The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men,” The Journal of Clinical Investigation, vol. 111, no. 9, pp. 1409–1421, 2003. View at Publisher · View at Google Scholar · View at Scopus
  2. M. Yannakoulia, N. Yiannakouris, S. Blüher, A.-L. Matalas, D. Klimis-Zacas, and C. S. Mantzoros, “Body fat mass and macronutrient intake in relation to circulating soluble leptin receptor, free leptin index, adiponectin, and resistin concentrations in healthy humans,” The Journal of Clinical Endocrinology & Metabolism, vol. 88, no. 4, pp. 1730–1736, 2003. View at Publisher · View at Google Scholar · View at Scopus
  3. G. Matarese, S. Moschos, and C. S. Mantzoros, “Leptin in immunology,” Journal of Immunology, vol. 174, no. 6, pp. 3137–3142, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. F. Malli, A. I. Papaioannou, K. I. Gourgoulianis, and Z. Daniil, “The role of leptin in the respiratory system: an overview,” Respiratory Research, vol. 11, article 152, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. C. S. Mantzoros, “The role of leptin in human obesity and disease: a review of current evidence,” Annals of Internal Medicine, vol. 130, no. 8, pp. 671–680, 1999. View at Publisher · View at Google Scholar · View at Scopus
  6. G. Brabant, R. Horn, A. von zur Mühlen et al., “Free and protein bound leptin are distinct and independently controlled factors in energy regulation,” Diabetologia, vol. 43, no. 4, pp. 438–442, 2000. View at Publisher · View at Google Scholar · View at Scopus
  7. J. A. Meyers, A. Y. Liu, A. McTiernan et al., “Serum leptin concentrations and markers of immune function in overweight or obese postmenopausal women,” Journal of Endocrinology, vol. 199, no. 1, pp. 51–60, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. M. K. Sinha, I. Opentanova, J. P. Ohannesian et al., “Evidence of free and bound leptin in human circulation. Studies in lean and obese subjects and during short-term fasting,” The Journal of Clinical Investigation, vol. 98, no. 6, pp. 1277–1282, 1996. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Schaab, H. Kausch, J. Klammt et al., “Novel regulatory mechanisms for generation of the soluble leptin receptor: implications for leptin action,” PLoS ONE, vol. 7, no. 4, Article ID e34787, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. J. L. Chan, S. Blüher, N. Yiannakouris, M. A. Suchard, J. Kratzsch, and C. S. Mantzoros, “Regulation of circulating soluble leptin receptor levels by gender, adiposity, sex steroids, and leptin observational and interventional studies in humans,” Diabetes, vol. 51, no. 7, pp. 2105–2112, 2002. View at Publisher · View at Google Scholar · View at Scopus
  11. M. Owecki, E. Nikisch, A. Miczke, D. Pupek-Musialik, and J. Sowiski, “Leptin, soluble leptin receptors, free leptin index, and their relationship with insulin resistance and BMI: high normal BMI is the threshold for serum leptin increase in humans,” Hormone and Metabolic Research, vol. 42, no. 8, pp. 585–589, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. S. S. Martin, A. Qasim, and M. P. Reilly, “Leptin resistance: a possible interface of inflammation and metabolism in obesity-related cardiovascular disease,” Journal of the American College of Cardiology, vol. 52, no. 15, pp. 1201–1210, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. P. Magni, A. Liuzzi, M. Ruscica et al., “Free and bound plasma leptin in normal weight and obese men and women: relationship with body composition, resting energy expenditure, insulin-sensitivity, lipid profile and macronutrient preference,” Clinical Endocrinology, vol. 62, no. 2, pp. 189–196, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. K. M. Sudi, S. Gallistl, M. H. Borkenstein et al., “Effects of weight loss on leptin, sex hormones, and measures of adiposity in obese children,” Endocrine, vol. 14, no. 3, pp. 429–435, 2001. View at Publisher · View at Google Scholar · View at Scopus
  15. L. U. Monzillo, O. Hamdy, E. S. Horton et al., “Effect of lifestyle modification on adipokine levels in obese subjects with insulin resistance,” Obesity Research, vol. 11, no. 9, pp. 1048–1054, 2003. View at Publisher · View at Google Scholar · View at Scopus
  16. F. S. L. Thong, R. Hudson, R. Ross, I. A. N. Janssen, and T. E. Graham, “Plasma leptin in moderately obese men: independent effects of weight loss and aerobic exercise,” American Journal of Physiology—Endocrinology and Metabolism, vol. 279, no. 2, pp. E307–E313, 2000. View at Google Scholar · View at Scopus
  17. M. Laimer, C. F. Ebenbichler, S. Kaser et al., “Weight loss increases soluble leptin receptor levels and the soluble receptor bound fraction of leptin,” Obesity Research, vol. 10, no. 7, pp. 597–601, 2002. View at Publisher · View at Google Scholar · View at Scopus
  18. B. E. Wolfe, D. C. Jimerson, C. Orlova, and C. S. Mantzoros, “Effect of dieting on plasma leptin, soluble leptin receptor, adiponectin and resistin levels in healthy volunteers,” Clinical Endocrinology, vol. 61, no. 3, pp. 332–338, 2004. View at Publisher · View at Google Scholar · View at Scopus
  19. F. M. H. van Dielen, C. van ’t Veer, W. A. Buurman, and J. W. M. Greve, “Leptin and soluble leptin receptor levels in obese and weight-losing individuals,” Journal of Clinical Endocrinology and Metabolism, vol. 87, no. 4, pp. 1708–1716, 2002. View at Publisher · View at Google Scholar · View at Scopus
  20. V. Nobili, M. Manco, P. Ciampalini et al., “Leptin, free leptin index, insulin resistance and liver fibrosis in children with non-alcoholic fatty liver disease,” European Journal of Endocrinology, vol. 155, no. 5, pp. 735–743, 2006. View at Publisher · View at Google Scholar · View at Scopus
  21. G. Catli, A. Anik, H. Ü. Tuhan, T. Kume, E. Bober, and A. Abaci, “The relation of leptin and soluble leptin receptor levels with metabolic and clinical parameters in obese and healthy children,” Peptides, vol. 56, pp. 72–76, 2014. View at Publisher · View at Google Scholar · View at Scopus
  22. C. Couillard, P. Mauriège, D. Prud'homme et al., “Plasma leptin concentrations: gender differences and associations with metabolic risk factors for cardiovascular disease,” Diabetologia, vol. 40, no. 10, pp. 1178–1184, 1997. View at Publisher · View at Google Scholar · View at Scopus
  23. F. Malli, A. I. Papaioannou, K. I. Gourgoulianis, and Z. Daniil, “The role of leptin in the respiratory system: an overview,” Respiratory Research, vol. 11, no. 1, article 152, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. M. Owecki, E. Nikisch, A. Miczke, D. Pupek-Musialik, and J. Sowiński, “Free leptin index as a marker for leptin action in diabetes and obesity: leptin and soluble leptin receptors relationship with HbA1c,” Neuroendocrinology Letters, vol. 31, no. 5, pp. 679–684, 2010. View at Google Scholar · View at Scopus
  25. V. Ogier, O. Ziegler, L. Méjean, J. P. Nicolas, and A. Stricker-Krongrad, “Obesity is associated with decreasing levels of the circulating soluble leptin receptor in humans,” International Journal of Obesity, vol. 26, no. 4, pp. 496–503, 2002. View at Publisher · View at Google Scholar · View at Scopus
  26. D. S. Weigle, P. B. Duell, W. E. Connor, R. A. Steiner, M. R. Soules, and J. L. Kuijper, “Effect of fasting, refeeding, and dietary fat restriction on plasma leptin levels,” The Journal of Clinical Endocrinology & Metabolism, vol. 82, no. 2, pp. 561–565, 1997. View at Publisher · View at Google Scholar · View at Scopus
  27. M. Kabir, M. Guerre-Millo, M. Laromiguiere, G. Slama, and S. W. Rizkalla, “Negative regulation of leptin by chronic high-glycemic index starch diet,” Metabolism: Clinical and Experimental, vol. 49, no. 6, pp. 764–769, 2000. View at Publisher · View at Google Scholar · View at Scopus
  28. M. S. D. Agus, J. F. Swain, C. L. Larson, E. A. Eckert, and D. S. Ludwig, “Dietary composition and physiologic adaptations to energy restriction,” American Journal of Clinical Nutrition, vol. 71, no. 4, pp. 901–907, 2000. View at Google Scholar · View at Scopus