Higher 2-year survival in high versus normal WC: 77.9% versus 64.3%, and high versus normal BMI: 89.8% versus 58.2%.
Retrospective analysis of data of patients seen at a specialist center for heart transplant patients selected based on disease severity and prognosis and thus not likely to be representative of all heart failure patients.
Lower risk of death as BMI increased until BMI > 45. Hazard ratios were 1.68 (95% CI, 1.04–2.69), 0.99 (95% CI, 0.71–1.36), 0.58 (95% CI, 0.35–0.97), 0.79 (95% CI, 0.44–1.4), and 1.38 (95% CI 0.74–2.6) for underweight, overweight, obese, and morbidly obese patients and BMI > 45 kg/m2, respectively. Thus, underweight and BMI > 45 kg/m2 were associated with increased risk of death.
Lower risk of death associated with increasing BMI. Using normal BMI as reference, hazard ratios were 1.21 (0.95–1.53), 0.88 (0.80–0.96), and 0.81 (0.72–0.92) for underweight, overweight, and obese patients, respectively.
Results were primarily for a Digitalis clinical trial; thus, results were reanalyzed with a new hypothesis that was specified after study.
TSF > 20 mm was a strong predictor of all-cause mortality. Hazard ratio = 0.36 (0.13–0.97, ). Results for other measures of body fat composition, BMI, WC, arm circumference (AC), Arm Muscle Circumference (AMC), and TSF, were not statistically significant in any direction.