Research Article

Web-Based Interventions Alone or Supplemented with Peer-Led Support or Professional Email Counseling for Weight Loss and Weight Maintenance in Women from Rural Communities: Results of a Clinical Trial

Table 5

Linear mixed tests of pairwise group comparisons of estimated difference in change by phase of intervention.

OutcomePhase 1Phase 2Phase 3
Baseline to 6 months6 months to 18 months18 months to 30 months
Pairwise comparisonEstimated mean difference (95% CI)Estimated mean difference (95% CI)Estimated mean difference (95% CI)

Body weight
 WO versus WD0.1380.9 (−0.8 to 2.7)0.3600.2 (−1.1 to 1.6)0.268−0.4 (−1.8 to 0.9)
 WO versus WE0.188−0.8 (−2.5 to 0.9)0.411−0.2 (−1.5 to 1.2)0.444−0.1 (−1.4 to 1.2)
 WD versus WE0.047−1.7 (−3.4 to 0.0)0.563−0.4 (−1.7 to 1.0)0.6320.3 (−1.0 to 1.7)
Waist circumference
 WO versus WD0.0701.6 (−0.5 to 3.7)0.497−0.01 (−1.5 to 1.4)0.479−0.04 (−1.5 to 1.4)
 WO versus WE0.4610.1 (−2.0 to 2.2)0.441−0.1 (−1.5 to 1.3)0.463−0.1 (1.5 to 1.3)
 WD versus WE0.164−1.5 (−3.5 to 0.6)0.891−0.1 (−1.6 to 1.4)0.970−0.03 (−1.5 to 1.4)
Kcal intake daily
 WO versus WD0.105−96.9 (−248.7 to 55.0)0.473−4.7 (−138.8 to 129.3)0.134−67.3 (−186.5 to 52.0)
 WO versus WE0.139−83.5 (−234.6 to 67.7)0.289−37.6 (−170.5 to 95.2)0.18353.6 (−62.8 to 170.0)
 WD versus WE0.86113.4 (−137.2 to 164.1)0.633−32.9 (−168.4 to 102.6)0.050120.9 (0.0 to 241.8)
Weekly minutes ≥ moderate intensity activity (Actigraph)
 WO versus WD0.497−0.2 (−38.3 to 37.9)0.27110.9 (−24.2 to 46.0)0.373−6.0 (−42.2 to 30.2)
 WO versus WE0.332−8.3 (−46.0 to 29.3)0.27010.9 (−24.1 to 45.9)0.24012.9 (−23.0 to 48.7)
 WD versus WE0.672−8.2 (−46.1 to 29.8)0.9990.02 (−35.6 to 35.7)0.31318.9 (−17.9 to 55.6)
Weekly minutes ≥ moderate intensity activity
 WO versus WD0.207−30.6 (−104.2 to 43.0)0.05551.6 (−11.7 to 114.8)0.344−10.1 (−59.8 to 39.6)
 WO versus WE0.4276.8 (−66.4 to 80.0)0.33613.5 (−49.1 to 76.1)0.288−13.8 (−62.5 to 34.8)
 WD versus WE0.31437.4 (−35.6 to 110.5)0.238−38.1 (−101.4 to 25.2)0.885−3.7 (−54.2 to 46.7)
Systolic blood pressure
 WO versus WD0.2091.3 (−1.9 to 4.6)0.318−0.9 (−4.8 to 2.9)0.4190.4 (−3.3 to 4.0)
 WO versus WE0.137−1.8 (−5.1 to 1.4)0.395−0.5 (−4.3 to 3.3)0.3100.9 (−2.7 to 4.5)
 WD versus WE0.054−3.2 (−6.4 to 0.1)0.8330.4 (−3.4 to 4.3)0.7820.5 (−3.2 to 4.2)
Diastolic blood pressure
 WO versus WD0.3170.5 (−1.4 to 2.3)0.431−0.2 (−2.4 to 2.0)0.468−0.1 (−2.2 to 2.1)
 WO versus WE0.216−0.7 (−2.6 to 1.1)0.215−0.9 (−3.1 to 1.3)0.3420.4 (−1.7 to 2.5)
 WD versus WE0.2051.2 (−3.0 to 0.7)0.548−0.7 (−2.9 to 1.6)0.6390.5 (−1.7 to 2.7)
Total cholesterol (mL/dL)
 WO versus WD0.4730.4 (−10.2 to 11.0)0.0947.2 (−3.5 to 17.9)0.154−4.3 (−12.7 to 4.0)
 WO versus WE0.026−10.4 (−20.8 to 0.1)0.0767.7 (−2.8 to 18.3)0.116−5.0 (−13.2 to 3.2)
 WD versus WE0.043−10.8 (−21.2 to −0.3)0.9180.6 (−10.2 to 11.3)0.873−0.7 (−9.2 to 7.8)
HDL (mL/dL)
 WO versus WD0.060−2.2 (−5.0 to 0.6)0.3650.4 (−2.1 to 3.0)0.1471.4 (−1.2 to 4.1)
 WO versus WE−4.0 (−6.8 to −1.3)0.0622.0 (−0.5 to 4.4)0.273−0.8 (−3.4 to 1.8)
 WD versus WE0.196−1.8 (−4.6 to 0.9)0.2411.5 (−1.0 to 4.0)0.105−2.2 (−4.9 to 0.5)
LDL (mL/dL)
 WO versus WD0.3501.6 (−6.7 to 10.0)0.0816.1 (−2.5 to 14.8)0.064−5.6 (−12.7 to 1.6)
 WO versus WE0.079−5.9 (−14.1 to 2.3)0.0238.7 (0.2 to 17.2)0.029−6.8 (−13.8 to 0.2)
 WD versus WE0.072−7.5 (−15.8 to 0.7)0.5612.6 (−6.1 to 11.3)0.732−1.3 (−8.5 to 6.0)
Triglycerides (mL/dL)
 WO versus WD0.3703.1 (−15.0 to 21.1)0.429−1.4 (−16.6 to 13.8)0.3373.2 (−11.9 to 18.4)
 WO versus WE0.4770.5 (−17.4 to 18.4)0.028−14.7 (−29.8 to 0.3)0.02315.3 (0.4 to 30.3)
 WD versus WE0.782−2.5 (−20.4 to 15.4)0.089−13.3 (−28.7 to 2.0)0.12312.1 (−3.3 to 27.5)
Fasting glucose (mL/dL)
 WO versus WD0.0812.7 (−1.1 to 6.5)0.141−2.0 (−5.7 to 1.7)0.3600.6 (−2.9 to 4.2)
 WO versus WE0.0243.8 (0.1 to 7.6)0.195−1.6 (−5.2 to 2.0)0.046−3.0 (−6.4 to 0.5)
 WD versus WE0.5651.1 (−2.7 to 4.9)0.8270.4 (−3.3 to 4.1)0.047−3.6 (−7.2 to 0.0)

maximum likelihood methods were used to analyze a mixed-effects repeated-measures model (random intercept, unstructured variance/covariance matrix), with tests of pairwise contrasts of group differences in the change in outcome from beginning to end of each phase.
of web-based with discussion board (WD) and web-based with email counseling (WE) with web-based only (WO) were one-tailed and WD with WE were two-tailed, each tested at .
also included data collected at 3, 12, and 24 months, but comparisons focused on group differences in change from the beginning to the end of each phase.
effect was not in hypothesized direction.