Effects of Immediate or Delayed Estradiol on Behavior in Old Menopausal Macaques on Obesogenic Diet

Figure 1

(a) The ImE-treated group exhibited higher duration of “alone” time during the protocol. In the 30-month (2.5 years) observations, there was a post hoc difference between the ImE group and the placebo or DE group (Bonferroni ). (b) The ImE-treated group showed a decline in “close social” behavior over time that was statistically manifested at the 30-month (2.5 years) time point (Inset). “Close social” behavior was significantly less in the ImE group when compared with the combined placebo + DE groups (t test ). (Title different by 2-way ANOVA (); graph different by post hoc test ()).

(a)

(b)