Research Article
The Single Nucleotide Polymorphism PPARG2 Pro12Ala Affects Body Mass Index, Fat Mass, and Blood Pressure in Severely Obese Patients
Table 3
Association between BMI categories and the genotypes in severely obese patients.
| | Genotypes | BMI (kg/m2) | value | Adjusted p valuea | | 35–49.9 | ≥50 |
| | PPARG2 Pro12Ala () | | | 0.123 | 0.154 | | ProPro () | 95 (74.8) | 32 (25.20) | | | | Ala carriers () | 11 (57.9) | 8 (42.1) | | | | IL6 -174G >C () | | | 0.907 | 0.851 | | GG () | 71 (74.0) | 25 (26.0) | | | | C carriers () | 38 (73.1) | 14 (26.9) | | | | Genotype combination () | | | 0.361† | 0.257 | | No variants () | 59 (75.6) | 19 (24.4) | | | | PPARG2 variant only () | 36 (75.0) | 12 (25.0) | | | | IL6 variant only () | 9 (60.0) | 6 (40.0) | | | | Both variants () | 2 (50.0) | 2 (50.0) | | |
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Data are presented as (%). BMI: body mass index. Chi-squared test; †Fisher’s exact test; aadjusted for age, gender, sedentary time, and diabetes. |
