FTO rs9939609 Does Not Interact with Physical Exercise but Influences Basal Insulin Metabolism in Brazilian Overweight and Obese Adolescents
Table 1
Initial and final averages of biochemical variables stratified by rs9939609 FTO SNP genotype and effect of exercise ( value training), genotype ( value genotype), and training × genotype interaction ( value T × G).
Variables
TT + AT (mean ± SD)
AA (mean ± SD)
value
n
Before
After
%Δ
n
Before
After
%Δ
Training
Genotype
T × G
TC (mg/dl)
118
163 ± 35.81
157 ± 32.79
−3.68
17
161 ± 31.75
148 ± 29.26
−8.07
0.002
0.55
0.20
HDL-C (mg/dl)
117
48 ± 10.9
46 ± 11.81
−4.17
17
52 ± 11.95
46 ± 9.91
−11.54
0.005
0.43
0.05
LDL-C (mg/dl)
118
94 ± 29.5
90 ± 27.42
−4.26
17
92 ± 24.27
83 ± 30.94
−9.78
0.02
0.44
0.34
TG (mg/dl)
117
104.44 ± 53.98
102.71 ± 52.84
−1.66
17
85.85 ± 30.35
98.06 ± 68.54
14.22
0.4
0.34
0.26
Glucose (mg/dl)
117
87 ± 9.39
86 ± 8.06
−1.15
18
82 ± 9.6
80 ± 5.76
−2.44
0.07
0.003
0.77
Insulin (uIU/ml)
94
15.54 ± 10.93
12.68 ± 7.81
−18.40
15
20 ± 14.06
17.58 ± 9.8
−12.10
0.02
0.07
0.84
HOMA-IR
48
1.86 ± 1.18
1.4 ± 0.88
−24.73
8
2.86 ± 1.73
2.53 ± 1.43
−11.54
0.06
0.007
0.74
QUICKI
43
0.34 ± 0.04
0.36 ± 0.04
5.88
7
0.32 ± 0.03
0.33 ± 0.03
3.13
0.03
0.07
0.70
TC: total cholesterol; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; TG: triglycerides; HOMA-IR: homeostatic model assessment for insulin resistance; QUICKI: quantitative insulin sensitivity check index; SD: standard deviation; %Δ: percentage variation; T × G: training × genotype interaction; the test applied was two-way mixed ANOVA.
