Body Mass Index at Pediatric Leukemia Diagnosis and the Risks of Relapse and Mortality: Findings from a Single Institution and Meta-analysis

Table 4

Association between obesity and relapse or mortality among pediatric ALL patients.

	Imputed				Complete set
Variables	HR	Lower 95% CI	Upper 95% CI	-value	HR	Lower 95% CI	Upper 95% CI	-value
Relapse
Unadjusted
Overweight/obese vs non-overweight	1.09	0.43	2.76	0.86	0.99	0.36	2.67	0.98
Sex and age adjusted
Overweight/obese vs non-overweight	1.00	0.35	2.84	0.99	0.88	0.31	2.48	0.81
Female vs male	0.79	0.37	1.69	0.55	0.65	0.27	1.55	0.33
Age at diagnosis	1.05	0.98	1.12	0.17	1.09	1.00	1.17	0.04
Multivariable adjusted
Overweight/obese vs non-overweight	0.95	0.32	2.84	0.93	0.74	0.22	2.46	0.62
Female vs male	0.71	0.33	1.53	0.38	0.65	0.25	1.68	0.37
Age at diagnosis	1.07	0.99	1.16	0.08	1.13	1.03	1.25	0.011
Public vs private	1.87	0.80	4.38	0.15	2.20	0.79	6.15	0.13
WBC at diagnosis	0.97	0.73	1.28	0.81	0.92	0.68	1.26	0.61
Mortality
Unadjusted
Overweight/obese vs non-overweight	2.58	0.84	7.92	0.10	2.83	0.95	8.46	0.06
Sex and age adjusted
Overweight/obese vs non-overweight	1.61	0.43	6.33	0.47	1.89	0.60	6.00	0.28
Female vs male	0.77	0.27	2.20	0.63	0.52	0.16	1.74	0.29
Age at diagnosis	1.20	1.09	1.33	<0.001	1.25	1.10	1.42	<0.001
Multivariable adjusted
Overweight/obese vs non-overweight	1.52	0.38	6.10	0.54	2.00	0.50	8.12	0.33
Female vs male	0.63	0.21	1.88	0.41	0.35	0.08	1.46	0.15
Age at diagnosis	1.21	1.09	1.34	<0.001	1.30	1.12	1.52	0.001
Government vs commercial	2.24	0.70	7.13	0.17	1.98	0.51	7.62	0.32
WBC at diagnosis	1.24	0.93	1.64	0.14	1.21	0.87	1.68	0.26

Hazard ratio.