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Journal of Obesity
Volume 2018, Article ID 7140754, 10 pages
Clinical Study

Effects of 6 Months of Active Commuting and Leisure-Time Exercise on Fibrin Turnover in Sedentary Individuals with Overweight and Obesity: A Randomised Controlled Trial

1Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
2Unit for Thrombosis Research, Department of Regional Health Research, University of Southern Denmark, Odense, Denmark
3Department of Clinical Biochemistry, Hospital of South West Jutland, Esbjerg, Denmark

Correspondence should be addressed to Anne Sofie Gram; kd.tedaarnicidem@gsa

Received 16 November 2017; Revised 5 March 2018; Accepted 15 April 2018; Published 16 May 2018

Academic Editor: Terry Huang

Copyright © 2018 Anne Sofie Gram et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Obesity and exercise constitute important factors for cardiovascular disease risk, but the long-term effects of different exercise modalities on haemostatic biomarkers are not well elucidated. We investigated the effects of 6 months of active commuting or leisure-time exercise on measures of fibrin turnover in individuals who are overweight and obese. Ninety younger (20–40 years), sedentary, healthy women and men who are overweight and obese (BMI: 25–35 kg/m2) were randomised to 6 months of habitual lifestyle (CON, ), active commuting (BIKE, ), or leisure-time exercise of moderate (MOD, ∼50% VO2peak reserve, ) or vigorous intensity (VIG, ∼70% VO2peak reserve, ). Fasting blood samples (baseline and 3 and 6 months) were analysed for cholesterols and triglycerides, thrombin generation, prothrombin fragment 1 + 2, D-dimer, fibrin clot properties, and fibrinolytic activity. We observed no differences between CON, BIKE, MOD, and VIG during the intervention and no time effects for any of the variables measured despite increased VO2peak in all exercise groups. We found no difference between CON and all exercise groups combined and no gender-specific effects of exercise. Our findings suggest that thrombin generation capacity, coagulation activation, fibrin clot structure, and lysability are unaffected by long-term active commuting and leisure-time exercise in women and men who are overweight and obese.