Effects of 6 Months of Active Commuting and Leisure-Time Exercise on Fibrin Turnover in Sedentary Individuals with Overweight and Obesity: A Randomised Controlled Trial

Table 3

Biomarkers of coagulation activation at baseline and at 3 and 6 months.

	CON ()	n^b	BIKE ()	n^b	MOD ()	n^b	VIG ()	n^b	values
ETP (nM⋅min)^a									0.314^c, 0.413^d, 0.555^e
Baseline	1985 (1819; 2166)	16	2049 (1803; 2328)	18	1975 (1859; 2097)	31	1883 (1750; 2026)	22
3 months	2000 (1844; 2171)	15	2143 (1957; 2346)	16	1963 (1832; 2103)	29	1970 (1849; 2094)	24
6 months	2078 (1907; 2358)	16	2108 (1884; 2358)	16	1965 (1844; 2094)	31	2008 (1858; 2126)	24
Time to peak (min)									0.882^c, 0.942^d, 0.453^e
Baseline	6.78 (6.26; 7.33)	16	6.46 (5.78; 7.15)	18	6.36 (5.97; 6.75)	30	6.87 (6.23; 7.51)	23
3 months	6.59 (5.97; 7.21)	15	6.24 (5.70; 6.79)	16	6.34 (5.93; 6.34)	29	6.85 (6.28; 7.44)	24
6 months	6.37 (5.66; 7.05)	16	6.28 (5.67; 6.89)	16	6.26 (5.84; 6.68)	31	6.57 (5.96; 7.19)	24
Start tail (min)^a									0.934^c, 0.490^d, 0.993^e
Baseline	26.7 (25.5; 27.9)	16	26.9 (25.6; 28.2)	18	26.5 (25.7; 27.2)	31	26.6 (25.5; 27.5)	22
3 months	27.0 (26.7; 28.4)	15	27.5 (26.3; 28.6)	16	27.0 (25.9; 28.1)	29	26.8 (25.7; 27.9)	24
6 months	26.9 (25.5; 28.9)	16	27.2 (25.8; 28.6)	16	27.5 (25.8; 21.2)	31	27.1 (25.9; 28.1)	24
Peak (nM)									0.550^c, 0.245^d, 0.522^e
Baseline	301 (264; 339)	16	309 (263; 354)	18	307 (285; 330)	30	283 (256; 313)	22
3 months	306 (274; 338)	15	327 (288; 365)	16	299 (273; 325)	29	289 (263; 314)	24
6 months	329 (289; 368)	16	321 (276; 367)	16	300 (271; 328)	31	303 (278; 327)	24
Lag time (min)^a									0.727^c, 0.845^d, 0.799^e
Baseline	3.40 (3.11; 3.71)	16	3.17 (2.87; 3.49)	18	3.26 (3.00; 3.53)	30	3.29 (2.91; 3.72)	22
3 months	3.39 (2.85; 3.44)	15	3.13 (2.85; 3.42)	16	3.16 (2.91; 3.45)	29	3.34 (2.98; 3.75)	24
6 months	3.26 (2.97; 3.58)	16	3.15 (2.82; 3.53)	16	3.15 (2.86; 3.27)	31	3.25 (2.92; 3.62)	24
Velocity index (nM/min)									0.398^c, 0.155^d, 0.372^e
Baseline	99 (82; 116)	16	107 (79; 134)	18	111 (96; 127)	30	91 (74; 106)	22
3 months	106 (89; 122)	15	114 (92; 135)	16	109 (91; 128)	29	91 (76; 105)	24
6 months	112 (86; 138)	16	124 (88; 160)	16	104 (90; 118)	31	103 (88; 117)	24
F1 + 2 (pmol/l)^a									0.474^c, 0.611^d, 0.758^e
Baseline	196 (149; 260)	16	212 (184; 245)	17	212 (184; 245)	30	174 (138; 218)	22
3 months	207 (169; 254)	14	198 (164; 240)	16	198 (164; 240)	30	207 (161; 265)	24
6 months	174 (140; 216)	16	223 (184; 271)	16	223 (184; 271)	30	182 (149; 222)	23
D-dimer (µg/l)^a									0.622^c, 0.439^d, 0.795^e
Baseline	0.26 (0.21; 0.32)	16	0.31 (0.25; 0.39)	18	0.29 (0.25; 0.34)	30	0.26 (0.21; 0.30)	23
3 months	0.27 (0.21; 0.35)	15	0.28 (0.21; 0.34)	16	0.27 (0.23; 0.31)	30	0.30 (0.25; 0.37)	24
6 months	0.23 (0.19; 0.29)	16	0.29 (0.23; 0.32)	18	0.27 (0.23; 0.31)	31	0.25 (0.21; 0.30)	24

Data are unadjusted mean (95% CI) or ^ageometric mean (geometric 95% CI); ^bnumber of samples available for analysis; ^c values for interactions between the group and time; ^d values for main effects of time for all groups combined; ^e values for between-group effects; CON, control group; BIKE, active commuting exercise group; MOD, moderate-intensity leisure-time exercise group; VIG, vigorous-intensity leisure-time exercise group; BMI, body mass index; ETP, endogenous thrombin potential; F1 + 2, prothrombin fragment 1 + 2.