Double-Blind, Randomized, Three-Armed, Placebo-Controlled, Clinical Investigation to Evaluate the Benefit and Tolerability of Two Dosages of IQP-AE-103 in Reducing Body Weight in Overweight and Moderately Obese Subjects

Table 5

Summary of changes in laboratory measurements during the study.

Measurements	Pre- to poststudy changes
	Low-dose IQP-AE-103 (mean ± s.d.)	High-dose IQP-AE-10 (mean ± s.d.)	Placebo (mean ± s.d.)	value
Hemoglobin (mmol/l)	−0.08 ± 0.48	0.09 ± 0.63	−0.04 ± 0.75	NS
Hematocrit (l/l)	−0.003 ± 0.029	−0.003 ± 0.028	−0.001 ± 0.036	NS
Erythrocytes (Tpt/l)	0.01 ± 0.31	0.02 ± 0.34	−0.02 ± 0.38	NS
Thrombocytes (Gpt/l)	8.6 ± 40.5	2.3 ± 42.1	0.8 ± 56.7	NS
Leukocytes (Gpt/l)	0.08 ± 1.55	−0.33 ± 1.65	0.16 ± 1.63	NS
Mean cell volume (fl)	−0.5 ± 3.5	−1.2 ± 5.4	0.1 ± 3.8	NS
Mean corpuscular hemoglobin (fmol/Ery)	−0.021 ± 0.058	0.013 ± 0.082	0.001 ± 0.076	NS
Mean corpuscular hemoglobin concentration (mmol/l)	−0.09 ± 0.95	0.24 ± 0.87	0.03 ± 0.96	NS
Alanine aminotransferase (μkat/l)	−0.075 ± 0.168	−0.035 ± 0.204	0.004 ± 0.211	NS
Aspartate aminotransferase (μkat/l)	−0.172 ± 0.483	−0.137 ± 0.566	0.028 ± 0.174	NS
Alkaline phosphatase (μkat/l)	0.026 ± 0.194	−0.150 ± 0.522	0.055 ± 0.305	NS
γ-Glutamyl transferase (μkat/l)	−0.083 ± 0.205	−0.042 ± 0.161	0.052 ± 0.346	NS
Bilirubin (μmol/l)	0.02 ± 6.76	4.35 ± 9.15	1.19 ± 7.89	NS
Creatinine (mmol/l)	0.26 ± 13.58	3.98 ± 9.37	1.92 ± 12.17	NS
Urea (mmol/l)	−0.17 ± 1.44	0.07 ± 1.24	−0.19 ± 1.32	NS
Uric acid (μmol/l)	−1.8 ± 60.9	−6.4 ± 77.3	11.7 ± 67.2	NS
Glucose (mmol/l)	−0.01 ± 0.63	0.01 ± 0.92	−0.16 ± 0.54	NS
Vitamin A (mg/l)	−0.002 ± 0.149	0.020 ± 0.173	0.063 ± 0.142	NS
Vitamin D (ng/l)	3.51 ± 13.45	4.37 ± 10.41	3.66 ± 11.79	NS
Vitamin E (mg/l)	−0.81 ± 3.11	−0.61 ± 3.07	1.09 ± 3.78	NS
Vitamin K (μg/l)	0.013 ± 1.197	0.086 ± 0.690	0.050 ± 0.689	NS
Vitamin K2mK4 (μg/l)	−0.002 ± 0.152	−0.022 ± 0.154	−0.031 ± 0.114	NS
Vitamin K2mK7 (μg/l)	0.143 ± 0.402	−0.157 ± 1.942	−0.086 ± 0.507	NS
Total cholesterol (mmol/l)	−0.08 ± 0.84	−0.30 ± 1.12	0.18 ± 1.09	NS
High-density lipoprotein cholesterol (mmol/l)	0.00 ± 0.39	0.10 ± 0.32	0.02 ± 0.39	NS
Low-density lipoprotein cholesterol (mmol/l)	−0.02 ± 0.77	−0.34 ± 1.04	0.03 ± 0.86	NS
Triglycerides (mmol/l)	0.00 ± 0.79	−0.09 ± 0.76	0.13 ± 0.39	NS
HbA1c (%)	0.14 ± 0.35	0.03 ± 0.34	0.11 ± 0.20	NS

Values from the Kruskal–Wallis test.