Impact of Obesity on Clinicopathologic Characteristics and Disease Prognosis in Pre- and Postmenopausal Breast Cancer Patients: A Retrospective Institutional Study
Table 2
Demographic and clinical characteristics of breast cancer patients (N = 348).
Characteristic
n (%)
Age at diagnosis (years)
50.98 ± 10.96 (24–83)
<45
110 (31.6)
45–60
166 (47.7)
>60
72 (20.7)
Marital status
Single
35 (10.1)
Married
301 (86.5)
Divorced
6 (1.7)
Widowed
4 (1.1)
Unknown
2 (0.6)
Smoking status
Current
30 (8.6)
Past
15 (4.3)
Never
297 (85.3)
Unknown
6 (1.7)
Alcohol intake
Yes
1 (0.3)
No
313 (89.9)
Unknown
34 (9.8)
HRT
Yes
12 (3.4)
No
278 (79.9)
Unknown
58 (16.7)
Menopausal status
Premenopausal
153 (44.0)
Postmenopausal
195 (56.0)
BMI (kg/m2)
29.52 ± 5.32 (15.9–45.5)
Underweight/normal
64 (18.4)
Overweight
118 (33.9)
Obese
166 (47.7)
Family history of breast cancer in first-degree relatives
Present
70 (20.1)
Absent
278 (79.9)
Site of disease
Right
159 (45.7)
Left
180 (51.7)
Bilateral
9 (2.6)
Histologic type
Invasive ductal carcinoma
277 (79.6)
Invasive lobular carcinoma
36 (10.3)
Other
35 (10.1)
Tumor stage
I
18 (5.2)
II
170 (48.9)
III
101 (29.0)
IV
59 (17.0)
Tumor grade
I (low grade)
38 (10.9)
II (intermediate grade)
128 (36.8)
III (high grade)
182 (52.3)
Tumor size
T1 (<2 cm)
38 (10.9)
T2 (2–5 cm)
220 (63.2)
T3 (>5 cm)
90 (25.9)
Lymph node status
Positive
249 (71.6)
Negative
99 (28.4)
LVI
Identified
256 (73.6)
Not identified
92 (26.4)
ER status
Positive
258 (74.1)
Negative
90 (25.9)
PR status
Positive
234 (67.2)
Negative
114 (32.8)
HER2 status
Positive
84 (24.1)
Negative
264 (75.9)
Molecular subtype
Luminal A
213 (61.2)
Luminal B
52 (14.9)
HER2-positive
32 (9.2)
Triple-negative
51 (14.7)
Surgery
None
6 (1.7)
Mastectomy
318 (91.4)
Breast conservation
18 (5.2)
Unknown
6 (1.7)
Adjuvant chemotherapy
Yes
282 (81.0)
No
26 (7.5)
Unknown
40 (11.5)
Mean ± SD (range). BMI, body mass index; ER, estrogen receptor; HER2, human epidermal growth factor receptor 2; HRT, hormone replacement therapy; LVI, lymphovascular invasion; PR, progesterone receptor. Other histologic subtypes included were ductal carcinoma in situ (DCIS) and mixed invasive ductal and lobular carcinoma.
