Are Nonnutritive Sweeteners Obesogenic? Associations between Diet, Faecal Microbiota, and Short-Chain Fatty Acids in Morbidly Obese Subjects
Table 3
Linear and ordinal regression analyses with the dysbiosis indices one at a time, and the six out of 41 faecal bacterial species/groups that were statistically significantly associated with nonnutritive sweeteners as the dependent variable, and starch, nonnutritive sweeteners, metformin, age (not shown), and gender (not shown) as independent variables.
Dependent variable
Starch
Nonnutritive sweeteners
Metformin
B (95% CI)
value
B (95% CI)
value
B (95% CI)
value
Dysbiosis Index
−0.002 (−0.007, 0.003)
0.455
0.049 (0.022, 0.077)
0.001
0.834 (0.122, 1.546)
0.022
Alternative Dysbiosis Index
−0.007 (−0.018, 0.004)
0.198
−0.090 (−0.143, −0.036)
0.001
1.676 (0.279, 3.074)
0.019
Faecalibacterium prausnitzii†
−0.003 (−0.012, 0.007)
0.583
−0.056 (−0.103, −0.009)
0.019
−1.142 (−2.312, 0.028)
0.056
Bacteroides fragilis†
−0.003 (−0.013, 0.008)
0.610
0.074 (0.025, 0.122)
0.003
0.416 (−0.899, 1.730)
0.536
Ruminococcus gnavus†
0.005 (−0.009, 0.018)
0.520
0.069 (0.009, 0.128)
0.024
0.793 (−0.928, 2.514)
0.367
Streptococcus spp.†
−0.009 (−0.023, 0.004)
0.156
0.093 (0.036, 0.150)
0.001
−0.658 (−2.143, 0.826)
0.385
Linear regression analyses. †Ordinal regression analyses.
