Journal of Obesity

Review Article

The Effects of Obesity on Outcome in Preclinical Animal Models of Infection and Sepsis: A Systematic Review and Meta-Analysis

Table 2

Survival, weight, fat mass, and glucose level table.


Study (author, year)	Exp #	Species	Obesity model		Weight (g)		Fat mass (g)		Glucose (mg/dl)		Control			Obese
Study (author, year)	Exp #	Species	Type	GT/DC	Control	Obese	Control	Obese	Control	Obese	Tot	Surv	Rep	Tot	Surv

Single-strain bacteria models
Hsu, 2007	1	Mo	Gen	ob/ob	NR	NR	NR	NR	NR	NR	10	9	1	17	3
Hsu, 2007	2	Mo	Gen	ob/ob/lep	NR	NR	NR	NR	NR	NR	10	9	1	18	8
Strandberg, 2009	3	Mo	Gen	ob/ob	28.8 ± 0.5	39.3 ± 1.1	NR	NR	NR	NR	15	12	0	18	5
Strandberg, 2009	4	Mo	DIO	HFD	28.8 ± 0.5	39.3 ± 1.1	5.5 ± 0.2	17.0 ± 0	NR	NR	21	18	0	18	8
Mancuso, 2014	5	Mo	Gen	CPE^F/F	20 ± 0.5	47.5 ± 1	NR	NR	120 ± 5	180 ± 5	6	2	0	6	3
Svahn, 2015	6	Mo	DIO	HFDP	30 ± 1	35 ± 1	7.0 ± 0.5	14 ± 0.5	NR	NR	20	13	1	20	17
	7	Mo	DIO	HFDS	30 ± 1	45 ± 1	7.0 ± 0.5	20.0 ± 0.5	NR	NR	20	13	1	20	4
	8	Mo	DIO	HFDS-HP	30 ± 1	45 ± 1	14.05 ± 0.5	20.0 ± 0.5	NR	NR	20	16	0	20	8
	9	Mo	DIO	HFDS-LP	30 ± 1	45 ± 1	14.05 ± 0.5	20.0 ± 0.5	NR	NR	20	17	0	20	8
Svahn, 2016	10	Mo	DIO	HFDS	39 ± 1	45 ± 1	15 ± 0.5	20.0 ± 0.5	NR	NR	20	14	1	20	3
Svahn, 2016	11	Mo	DIO	HFDw6	39 ± 1	42.5 ± 1	15 ± 0.5	20.0 ± 0.5	NR	NR	20	14	1	20	8
Wan, 2016	12	Mo	DIO	HFD	37.5 ± 1	47.5 ± 1	NR	NR	225 ± 40	350 ± 25	18	18	0	18	18
Wan, 2016	13	Mo	DIO	HFD	37.5 ± 1	47.5 ± 1	NR	NR	225 ± 40	350 ± 25	18	15	0	18	10
Cecal ligation and puncture models
Tschop, 2010	14	Mo	Gen	ob/ob	NR	NR	NR	NR	NR	NR	20	4	1	20	0
	15	Mo	DIO	HFD	NR	NR	NR	NR	NR	NR	20	4	1	7	4
	16	Mo	Gen	ob/ob	NR	NR	NR	NR	NR	NR	11	3	0	11	0
Kaplan, 2012	17	Mo	DIO	HFD	23.4 ± 0.4	25.2 ± 0.4	MRI	MRI-inc	NR	NR	12	6	0	12	1
Siegl, 2014	18	Mo	DIO	HFD	27.7 ± 0.2	34.4 ± 0.5	NR	NR	NR	NR	10	1	0	14	10
Kaplan, 2016	19	Mo	DIO	HFD	27 ± 0.5	33 ± 1	2 ± 0.5	9.6 ± 2	165 ± 5	190 ± 5	12	4	0	12	2
Lipopolysaccharide
Fagioni, 1998	20	Mo	Gen	ob/ob	20	40	NR	NR	100 ± 5	190 ± 5	5	5	0	5	3
	21	Mo	Gen	ob/ob	20	40	NR	NR	100 ± 5	190 ± 5	5	5	0	5	2
	22	Mo	Gen	ob/ob	20	40	NR	NR	100 ± 5	190 ± 5	5	4	0	5	0
	23	Mo	Gen	db/db	20	40	NR	NR	110 ± 5	310 ± 50	5	4	0	5	4
	24	Mo	Gen	db/db	20	40	NR	NR	110 ± 5	310 ± 50	5	1	0	5	1
	25	Mo	Gen	db/db	20	40	NR	NR	110 ± 5	310 ± 50	5	0	0	5	0
Segersvard, 2003	26	Ra	DIO	HFD35	415 ± 9	436 ± 8	3.4 ± 0.2	5.2 ± 0.2	NR	NR	12	10	1	16	9
Segersvard, 2003	27	Ra	DIO	HFD60	415 ± 9	466 ± 5	3.4 ± 0.2	6.2 ± 0.2	NR	NR	12	10	1	16	10
Suto, 2007	28	Mo	Gen	B6AY12-	19.6	25.1	NR	NR	NR	NR	20	20	0	20	18
	29	Mo	Gen	B6Ay12-	19.6	25.1	NR	NR	NR	NR	20	17	1	20	7
	30	Mo	Gen	B6-ob/ob	19.6	52.8	NR	NR	NR	NR	20	17	1	24	0
	31	Mo	Gen	B6Ay12-	19.6	25.1	NR	NR	NR	NR	15	6	0	15	0
	32	Mo	Gen	B6Ay10m	19.6	51	NR	NR	NR	NR	6	2	0	5	0
	33	Mo	Gen	B6Ay10m	19.6	51	NR	NR	NR	NR	11	2	0	10	0
Sakai, 2013	34	Ra	DIO	HFD	289 ± 3.5	310.6 ± 1.9	3.2 ± 0.3	6.8 ± 0.3	102.0 ± 2.2	116 ± 3.7	7	6	0	8	1
Fujiwara, 2014	35	Ra	DIO	HFD	275 ± 1	294 ± 2.8	NR	NR	NR	NR	10	9	0	10	9
Fujiwara, 2014	36	Ra	DIO	HFD	450 ± 1	504.4 ± 7.3	NR	NR	NR	NR	7	5	0	7	1
Single-strain virus models
Smith, 2007	37	Mo	DIO	HFD	NR	NR	NR	NR	86 ± 3	108 ± 9	18	17	0	18	10
Easterbrook, 2011	38	Mo	DIO	HFD	NR	NR	NR	NR	NR	NR	5	5	0	5	1
	39	Mo	DIO	HFD	NR	NR	NR	NR	NR	NR	5	5	0	5	5
	40	Mo	DIO	HFD	NR	NR	NR	NR	NR	NR	5	0	0	5	0
Milner, 2013	41	Mo	DIO	HFD-UP	30 ± 1	42.5 ± 1	NR	NR	NR	NR	4	0	0	4	0
Milner, 2013	42	Mo	DIO	HFD-P	30 ± 1	42.5 ± 1	NR	NR	NR	NR	46	46	0	46	44
Radigan, 2014	43	Mo	Gen	db/db	20–25	30–35	NR	NR	NR	NR	10	3	0	10	0
Radigan, 2014	44	Mo	Gen	db/db	20–25	30–35	NR	NR	NR	NR	10	0	0	10	0
O’Brien, 2015	45	Mo	DIO	HFD	21	35	NR	NR	NR	NR	28	22	1	28	3
	46	Mo	Gen	ob/ob	21	53	NR	NR	NR	NR	28	22	1	28	6
	47	Mo	DIO	HFD	21	35	NR	NR	NR	NR	28	21	1	28	0
	48	Mo	Gen	ob/ob	21	53	NR	NR	NR	NR	28	21	1	28	0
Milner, 2015	49	Mo	DIO	HFD	30 ± 1	42.5 ± 1	NR	NR	70 ± 5	105 ± 5	21	21	0	21	4
	50	Mo	DIO	HFD	30 ± 1	42.5 ± 1	NR	NR	70 ± 5	105 ± 5	12	2	0	12	0
	51	Mo	Gen	LepR^H-/-	30 ± 1	42.5 ± 1	NR	NR	NR	NR	20	18	0	10	5
	52	Mo	Gen	LepR^H-/-	30 ± 1	42.5 ± 1	NR	NR	NR	NR	20	19	0	13	4

Exp: experiment; db/db: leptin receptor-deficient mice; DC: diet composition; DIO: diet-induced obesity; Gen: genetic; GT: genotype; HFD: high-fat diet; Mo: mouse; NR: not recorded; ob/ob: leptin-deficient mice; Ra: Rat; Rep: repeating control animals; Surv: number of animals surviving; Tot: total number of animals studied; wk: week. Noted increased fat mass on MRI but not quantitated; total fat mass weights calculated based on animal total weights (see methods).