Could Obesity be a Triggering Factor for Endometrial Tubal Metaplasia to be a Precancerous Lesion?

Figure 2

(a) An immunohistochemistry panel for ETM case (a case with BMI 38 kg/m² and serum estradiol level 420 ng/ml showing glands lined with tubal-like epithelium with adjacent benign endometrial glands without metaplasia (H&E X 40)), (b) PAX2 complete negative expression (score 1) in glands with tubal metaplasia and positive nuclear expression in the adjacent nonmetaplastic glands (X 40), (c) H-TERT strong diffuse positive nuclear expression score 3 (X 100), (d) P16 focal strong nuclear and cytoplasmic expression score 1 (X 100), (e) Ki67 strong nuclear expression score 3 (X 100), and (f) P53 focal strong nuclear expression score 2 (X 100).

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