Could Obesity be a Triggering Factor for Endometrial Tubal Metaplasia to be a Precancerous Lesion?

Table 4

Relation between BMI and other parameters in group 1 (n = 57).

	BMI		Test of sig.
	Nonobese (<30) (n = 34)	Obese (≥30) (n = 23)
Age (years)
Mean ± SD	43.1 ± 10.7	58.5 ± 12.2	t = 5.038	<0.001
Median (min.–max.)	38.5 (28–68)	64 (37–72)
Menopausal status
Premenopausal	26 (76.5%)	6 (26.1%)	χ^2 = 14.144	<0.001
Postmenopausal	8 (23.5%)	17 (73.9%)
Oral contraceptive history
Negative	21 (61.8%)	8 (34.8%)	χ^2 = 3.996	0.046
Positive	13 (38.2%)	15 (65.2%)
Atypia
No atypia	18 (52.9%)	14 (60.9%)	χ^2 = 0.350	0.554
Atypia	16 (47.1%)	9 (39.1%)
Serum estradiol level
≤300	34 (100%)	3 (13%)	χ^2 = 45.546	<0.001
>300	0 (0%)	20 (87%)
Mean ± SD	160.4 ± 62.6	377 ± 66.3	U = 2.0	<0.001
Median (min. –max.)	150 (60–290)	420 (280–450)
PAX-2
Negative	2 (5.9%)	21 (91.3%)	χ^2 = 41.592	<0.001
Positive	32 (94.1%)	2 (8.7%)
H-TERT
Negative	33 (97.1%)	3 (13%)	χ^2 = 41.618	<0.001
Positive	1 (2.9%)	20 (87%)
P16
Negative	29 (85.3%)	5 (21.7%)	χ^2 = 23.024	<0.001
Positive	5 (14.7%)	18 (78.3%)
Ki67
Negative	2 (5.9%)	0 (0%)	χ^2 = 1.402	0.510
Positive	32 (94.1%)	23 (100%)
P53
Negative	28 (82.4%)	3 (13%)	χ^2 = 26.566	<0.001
Positive	6 (17.6%)	20 (87%)

χ²: chi-square test; t: Student’s t-test; U: Mann-Whitney test. : value for association between BMI and different markers. Statistically significant at .