| Cardiometabolic risk markers | Weight loss intervention phase (baseline to 6 months) | Control | Intervention | >2% gain | ±2% maintain | >2–<5% loss | 5–20% loss | value | >2% gain | ±2% maintain | >2–<5% loss | 5–20% loss | -value | n = 18 | n = 48 | n = 29 | n = 19 | | n = 15 | n = 57 | n = 45 | n = 12 |
| WC, cm | −1.27 | −1.88 | −3.51 | −7.63abc | <0.001 | −0.77 | −2.14 | −4.24 | −5.67a | 0.002 | (−3.70, 1.16) | (−3.35, −0.41) | (−5.39, −1.62) | (−9.96, −5.29) | | (−2.86, 1.31) | (−3.20, −1.08) | (−5.44, −3.04) | (−7.98, −3.36) | | FPG, mmol/L | −0.37 | 0.09 | −0.05 | −0.12 | 0.434 | −0.03 | 0.07 | −0.35 | −0.19 | 0.065 | (−0.85, 0.10) | (−0.20, 0.38) | (−0.42, 0.33) | (−0.59, 0.34) | | (−0.08, 0.38) | (−0.48, 0.27) | (−0.33, 0.16) | (−0.67, 0.03) | | Fasting insulin, μU/mL | 0.79 | 0.37 | −0.38 | −1.32 | 0.346 | −1.08 | 0.99 | −0.36 | −4.27a | 0.022 | (−0.34, 0.77) | (−0.79, 1.52) | (−1.86, 1.10) | (−3.19, 0.54) | | (−3.91, 1.74) | (−0.43, 2.41) | (−1.95, 1.24) | (−7.35, −1.19) | | HOMA-IR | 0.22 | 0.17 | −0.17 | −0.45 | 0.218 | −0.55 | 0.07 | −0.48 | −0.63 | 0.190 | (−0.66, 1.84) | (−0.19, 0.53) | (−0.63, 0.29) | (−1.02, 0.12) | | (−1.34, 0.24) | (−0.33, 0.46) | (−0.92, −0.03) | (−1.48, 0.23) | | Triglycerides, mmol/L | 0.02 | −0.01 | 0.28 | 0.11 | 0.253 | 0.14 | 0.18 | 0.07 | −0.25 | 0.166 | (−0.28, 0.31) | (−0.19, 0.17) | (0.05, 0.51) | (−0.18, 0.40) | | (−0.17, 0.45) | (0.02, 0.34) | (−0.11, 0.25) | (−0.60, 0.10) | | TC, mmol/L | −0.10 | −0.32 | −0.26 | −0.32 | 0.760 | −0.31 | −0.30 | 0.03 | −0.59 | 0.022 | (−0.45, 0.24) | (−0.53, −0.11) | (−0.53, 0.01) | (−0.65, 0.02) | | (−0.67, 0.06) | (−0.48, −0.11) | (−0.18, 0.24) | (−0.99, −0.19) | | HDL-C, mmol/L | −0.04 | −0.04 | −0.09 | −0.05 | 0.674 | −0.04 | 0.01 | −0.01 | −0.01 | 0.880 | (−0.13, 0.06) | −0.10, 0.02) | (−0.17, −0.02) | (−0.14, 0.04) | | (−0.15, 0.07) | (−0.05, 0.07) | (−0.08, 0.05) | (−0.13, 0.12) | | LDL-C, mmol/L | −0.35 | −0.02 | −0.07 | −0.37 | 0.412 | −0.23 | −0.11 | 0.06 | 0.08 | 0.563 | (−0.79, 0.10) | (−0.29, 0.26) | (−0.42, 0.28) | (−0.81, 0.06) | | (−0.65, 0.20) | (−0.33, 0.10) | (−0.19, 0.30) | (−0.39, 0.55) | | TNF-α, pg/mL | 2.76 | 4.52 | 4.50 | 3.66 | 0.613 | 0.23 | 2.43 | 4.15 | 5.65 | 0.182 | (0.44, 5.09) | (3.04, 6.00) | (2.62, 6.37) | (1.35, 5.98) | | (−3.78, 4.25) | (0.45, 4.42) | (2.04, 6.26) | (1.80, 9.49) | | Adiponectin, μg/mL | 0.89 | −2.11 | −1.81 | 5.46ab | <0.001 | 1.94 | 1.86 | −0.30 | −1.75 | 0.403 | (−1.87, 3.64) | (−3.93, −0.28) | (−3.91, 0.28) | (2.48, 8.43) | | (−2.58, 6.47) | (−0.22, 3.94) | (−2.61, 2.01) | (−5.81, 2.32) | | Hs-CRP, mg/L | 1.92 | 0.62 | 0.74 | 0.58 | 0.779 | 0.83 | −1.15 | −1.57 | 0.60 | 0.110 | (−0.33, 4.16) | (−0.79, 2.03) | (−0.99, 2.47) | (−1.49, 2.65) | | (−1.37, 3.03) | (−2.21, −0.09) | (−2.72, −0.43) | (−1.48, 2.68) | |
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