Metabolomic Links between Sugar-Sweetened Beverage Intake and Obesity
Table 2
Twenty-eight metabolites associated with both SSB intake and BMI.
Metabolites
log (met)# and SSB intake
BMI and SSB intake
Beta
SE
value
Beta
SE
value
1-Oleoyl-GPC (18 : 1)
−4.917
0.792
8.80E − 10
0.028
0.013
0.030
5-Hydroxylysine
2.001
0.368
7.01E − 08
0.047
0.023
0.041
1-Palmitoyl-GPC (16 : 0)
−7.337
1.473
7.84E − 07
0.020
0.009
0.030
Glycine
−4.062
0.825
1.04E − 06
0.025
0.013
0.047
1,2-Dilinoleoyl-GPC (18 : 2/18 : 2)
−2.976
0.666
9.14E − 06
0.039
0.016
0.014
3-Phenylpropionate (hydrocinnamate)
−0.699
0.157
9.97E − 06
−0.143
0.061
0.018
1-Linoleoyl-2-linolenoyl-GPC (18 : 2/18 : 3)
−0.910
0.240
1.57E − 04
0.076
0.030
0.011
9-Hydroxystearate
1.332
0.354
1.84E − 04
0.077
0.027
5.15E − 03
Gamma-tocopherol/beta-tocopherol
1.566
0.418
1.95E − 04
0.044
0.022
0.044
1-Linoleoyl-GPE (18 : 2)
−1.356
0.368
2.44E − 04
0.061
0.019
0.001
1-Oleoyl-GPI (18 : 1)
−1.205
0.339
3.93E − 04
0.053
0.025
0.033
1-Oleoyl-GPE (18 : 1)
−1.216
0.366
9.42E − 04
0.049
0.021
0.020
1-Palmitoyl-2-stearoyl-GPC (16 : 0/18 : 0)
−2.571
0.783
1.08E − 03
0.036
0.012
2.28E − 03
2-Hydroxybutyrate/2-hydroxyisobutyrate
1.222
0.376
1.21E − 03
−0.068
0.024
4.43E − 03
Alpha-ketoglutarate
6.231
1.922
1.24E − 03
0.066
0.029
0.021
N-Acetylhistidine
−1.176
0.385
2.32E − 03
0.084
0.027
1.93E − 03
Butyrylcarnitine (C4)
0.369
0.134
5.83E − 03
0.051
0.023
0.025
Cholesterol
−1.103
0.400
5.97E − 03
0.030
0.014
0.039
3-Hydroxybutyrylcarnitine (1)
0.629
0.234
7.27E − 03
−0.138
0.049
4.92E − 03
Methyl-4-hydroxybenzoate sulfate
−0.189
0.071
7.84E − 03
0.174
0.080
0.030
1-Stearoyl-2-linoleoyl-GPC (18 : 0/18 : 2)
−2.975
1.218
0.015
0.016
0.008
0.033
1-Palmitoyl-GPC (16 : 1)
−0.893
0.367
0.015
0.071
0.017
4.27E − 05
Sphingomyelin (d18 : 2/14 : 0, d18 : 1/14 : 1)
0.706
0.299
0.018
0.048
0.018
0.009
3-Hydroxyisobutyrate
0.882
0.389
0.024
−0.044
0.021
0.036
3-Hydroxybutyrylcarnitine (2)
0.783
0.348
0.025
−0.063
0.026
0.014
Sphingomyelin (d18 : 1/20 : 0, d16 : 1/22 : 0)
−1.620
0.772
0.036
−0.028
0.011
0.011
1,5-Anhydroglucitol (1,5-AG)
−1.086
0.521
0.037
0.090
0.040
0.024
Erythronate
1.684
0.838
0.045
0.026
0.012
0.033
All beta and values were adjusted for age, sex, alcohol use, smoking, education, physical activity, and total energy intake. #Metabolite concentrations were natural log-transformed.
