Associations of Biomarkers of Inflammation and Breast Cancer in the Breast Adipose Tissue of Women with Combined Measures of Adiposity

Table 2

Breast adipose tissue biomarker mRNA expression according to combined adiposity (n = 141).

Biomarkers		n	Geometric means^a		value ^b	Ratio^c		value ^b
			(95% Cl)			(95% CI)
CYP19A1	BMI^LOWC^LO	59	0.022	(0.016–0.032)	0.0899	1	Ref.
	BMI^HIWC^LO	9	0.027	(0.011–0.066)		1.22	(0.46–3.21)	0.6904
	BMI^LOWC^HI	10	0.056	(0.016–0.199)		2.53	(0.68–9.39)	0.1672
	BMI^HIWC^HI	63	0.039	(0.029–0.053)		1.77	(1.11–2.82)	0.0184
ER-α	BMI^LOWC^LO	59	0.216	(0.181–0.258)	0.3641	1	Ref.
	BMI^HIWC^LO	9	0.199	(0.137–0.289)		0.92	(0.61–1.39)	0.6932
	BMI^LOWC^HI	10	0.185	(0.110–0.313)		0.86	(0.49–1.49)	0.5879
	BMI^HIWC^HI	63	0.171	(0.142–0.205)		0.79	(0.61–1.02)	0.0777
AIF1	BMI^LOWC^LO	35	0.068	(0.044–0.107)	0.0633	1	Ref.
	BMI^HIWC^LO	3	0.129	(0.024–0.705)		1.89	(0.33–10.80)	0.4768
	BMI^LOWC^HI	7	0.285	(0.069–1.180)		4.17	(0.93–18.76)	0.0671
	BMI^HIWC^HI	29	0.145	(0.100–0.210)		2.12	(1.17–3.86)	0.0163
COX2	BMI^LOWC^LO	34	0.192	(0.122–0.300)	0.0900	1	Ref.
	BMI^HIWC^LO	3	0.144	(0.060–0.344)		0.75	(0.29–1.96)	0.5619
	BMI^LOWC^HI	7	0.386	(0.149–0.999)		2.01	(0.69–5.90)	0.2074
	BMI^HIWC^HI	29	0.383	(0.259–0.566)		2.00	(1.08–3.69)	0.0312
IL-6	BMI^LOWC^LO	35	0.464	(0.300–0.719)	0.0085	1	Ref.
	BMI^HIWC^LO	3	0.654	(0.183–2.343)		1.41	(0.37–5.35)	0.6162
	BMI^LOWC^HI	7	1.489	(0.589–3.764)		3.21	(1.12–9.17)	0.0333
	BMI^HIWC^HI	29	1.373	(0.915–2.060)		2.96	(1.59–5.49)	0.0010
TNF-α	BMI^LOWC^LO	31	0.006	(0.005–0.009)	0.0006	1	Ref.
	BMI^HIWC^LO	2	0.004	(0.002–0.008)		0.67	(0.32–1.40)	0.2917
	BMI^LOWC^HI	5	0.020	(0.007–0.060)		3.18	(1.06–9.55)	0.0436
	BMI^HIWC^HI	26	0.016	(0.011–0.022)		2.49	(1.55–4.01)	0.0004
LEP	BMI^LOWC^LO	35	1.005	(0.766–1.319)	0.0002	1	Ref.
	BMI^HIWC^LO	3	1.734	(1.204–2.497)		1.73	(1.11–2.68)	0.0176
	BMI^LOWC^HI	7	2.323	(1.440–3.747)		2.31	(1.31–4.08)	0.0052
	BMI^HIWC^HI	29	2.502	(1.927–3.250)		2.49	(1.69–3.68)	<0.0001

CYP19A1 = cytochrome P450 family 19 subfamily A member 1; ER-α = estrogen receptor-alpha; AIF1 = allograft inflammatory factor 1; COX2 = cyclooxygenase-2; IL-6 = interleukin-6; TNF-α = tumor necrosis factor-alpha; LEP = leptin. ^aBack-transformed least-square means and confidence intervals (CI) from mixed-effects model performed on natural log-transformed values, adjusted for age at surgery, menopausal status, and PCR batch.^b values were calculated with mixed models performed on the logarithms of biomarker level data. values in bold indicate  < 0.05. ^cLeast-square geometric mean ratio compared with adiposity category BMI^LOWC^LO (reference) after adjusting for age, menopausal status, and PCR batch.