A Case-Control Study of the Association of Leptin Gene Polymorphisms with Plasma Leptin Levels and Obesity in the Kerala Population

Figure 2

(a–h) Part of sequence chromatogram showing LEP rs6976701 variants in study subjects. (a) Heterozygous genotype (AG) in case (P289); (b) heterozygous genotype (AG) in obese (P286); (c) heterozygous genotype (AG) in case (P203); (d) heterozygous genotype (AG) in case (P288); (e) heterozygous genotype (AG) in case (P055); (f) homozygous genotype (AA) in case (P292); (g) homozygous genotype (GG) in control (C253); (h) homozygous genotype (GG) in case (P089). (i-j) Part of sequence chromatogram showing LEP Thr5Thr (C/G). The missense codon is marked. (i) Heterozygous (CG) in case (P184); (j) homozygous (CC) in control (C177). (k–n) A part of sequence chromatogram showing missense mutation Phe17Leu. (k) Heterozygous (GT) genotype in case (P169); (l) homozygous genotype in control (C300); (m) heterozygous (GT) genotype in case (P202); (n) homozygous genotype (TT) in case (P116). (o–r) A part of sequence chromatogram showing missense mutation Lys 36 Arg. The missense codon is shown in the box. AAG codes for Lys and AGG codes for Arg. (o) Homozygous AA in case (P055); (p) missense mutation AG (Lys 36Arg) in case (P171); (q) homozygous AA in control (C061); (r) homozygous AA in case (P288).