Research Article
A Case-Control Study of the Association of Leptin Gene Polymorphisms with Plasma Leptin Levels and Obesity in the Kerala Population
Table 4
LEP + 19G/A alleles and selected study variables.
| | Study variable | Case (obesity group) | Control | | Alleles | value | Alleles | value | | G (n = 72) | A (n = 32) | G (n = 58) | A (n = 44) |
| | Age (yrs) | 43.8 ± 1.5 | 42.9 ± 2.0 | 0.74 | 34.8 ± 1.9 | 40.1 ± 2.0 | 0.07 | | BMI (kg/m2) | 27.8 ± 0.3 | 31.1 ± 0.6 | 0.001 | 21.1 ± 0.4 | 23.7 ± 0.2 | 0.001 | | Waist circumference (cm) | 98.3 ± 1.0 | 100.9 ± 1.8 | 0.18 | 80.5 ± 1.7 | 87.9 ± 1.5 | 0.002 | | Hip circumference (cm) | 102.4 ± 0.96 | 110.2 ± 1.5 | 0.001 | 89.4 ± 1.5 | 95.6 ± 1.9 | 0.01 | | WHR | 0.92 ± 0.01 | 0.96 ± 0.01 | 0.001 | 0.9 ± 0.01 | 0.93 ± 0.02 | 0.24 | | BF (%) | 33.2 ± 1.3 | 42.5 ± 1.5 | 0.001 | 25.8 ± 1.1 | 30.1 ± 1.8 | 0.03 | | Leptin (ng/ml) | 45.96 ± 6.9 | 84.2 ± 11.2 | 0.004 | 9.4 ± 1.2 | 26.6 ± 7.5 | 0.01 | | Insulin (µIU/ml) | 31.8 ± 3.6 | 36.2 ± 5.4 | 0.49 | 17.2 ± 3.6 | 19.6 ± 3.6 | 0.64 | | HOMA-IR | 15.6 ± 1.5 | 19.5 ± 2.8 | 0.19 | 10.1 ± 2.6 | 8.9 ± 1.5 | 0.7 |
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Data are expressed as mean ± SEM analysed by one way ANOVA. significant. |
