Review Article
The Role of Adipose Tissue in Insulin Resistance in Women of African Ancestry
Table 2
Ethnic differences in the relationship between circulating inflammatory markers and insulin resistance.
| Inflammatory marker | Ethnic difference | Moderating factors | Association with risk | References |
| hsCRP | Black > white | BMI and SES attenuate the difference between ethnic groups | Significant association with IR in both black and white populations | Festa et al. [49] | IL-6 | Black > white | Minor attenuation after adjusting for body fatness | Significant association with IR in white women only | Hyatt et al. [50] | IL-18 | Black > white/Hispanic | Not defined | Significant associations with IR glucose in both black and white populations | Zirlik et al. [51] | Adiponectin | White > black | Still significant after adjustment for age, BMI, or WHR | Significant associations with IR in white women only | Ferris et al. [52]; Hulver et al. [53] |
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hsCRP: high-sensitivity C-reactive protein; BMI: body mass index; SES: socioeconomic status; IL: interleukin; IR: insulin resistance; WHR: waist-hip ratio.
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