Risk Factors for Age-Related Maculopathy

Table 8

Studies investigating the relationship between indicators of inflammation and risk for ARM.

Study	No. of cases	Measure of risk factor	Type of ARM	Odds ratio or relative risk	95% confidence interval
Cross-Sectional Studies
Atherosclerosis Risk in Communities Study	11264	White blood cell count	Early and late ARM	N/A	N/A
National Health and Nutrition Examination Survey III [26, 54]	8270	Serum albumin	Early ARM	0.97	0.95–1.00
Cardiovascular Health Study [193]	2361	Serum albumin	Early ARM	0.59	0.39–0.92
		Plasma Fibrinogen	Early ARM	N/A	N/A
Cardiovascular Health Study [193]	2755	C-reactive protein	Early and Late ARM	1.24	0.87–1.78 (4th Quartile)
Beaver Dam Eye Study [194, 195]	2764	Gout	Early ARM	0.69	0.41–1.16
			Late ARM	2.18	1.06–4.47
		Emphysema	Early ARM	1.11	0.49–2.51
			Late ARM	2.55	0.74–8.81
Beaver Dam Eye Study [194, 195]	3684	NSAIDs	Early ARM	1.04	0.78–1.38
		Aspirin	Early ARM	1.08	0.79–1.48
		Oral steroids	Early ARM	0.80	0.28–2.28
Blue Mountains Eye Study [196]	2313	Steroids or NSAIDs	Early ARM	1.2	0.8–1.6
			Late ARM	0.9	0.4–1.9
Beaver Dam Eye Study [194, 195]	2764	White blood cell count	Early ARM	1.03	0.98–1.10
			Late ARM	0.99	0.86–1.14
		Serum albumin	Early ARM	0.91	0.64–1.29
			Late ARM	0.52	0.24–1.14