Effect of Trandolapril on Regression of Retinopathy in Hypertensive Patients with Type 2 Diabetes: A Prespecified Analysis of the Benedict Trial
Table 1
Baseline characteristics of hypertensive patients with type 2 diabetes and normoalbuminuria according to availability of fundus evaluation YES/NO, evidence of retinopathy at study entry YES/NO, and to randomization to ACE inhibitor therapy YES/NO and ndCCB therapy YES/NO.
Funduscopy Yes
Funduscopy No
Retinopathy Yes
Retinopathy No
With Retinopathy
ACEi Yes
ACEi No
ndCCB Yes
ndCCB No
Number of patients
550
659
90
460
42
48
50
40
Demography
Age (yrs)
62.0 7.8
62.6 ± 8.2
61.3 ± 7.9
62.1 ± 7.8
61.5 ± 7.7
61.1 ± 8.1
60.8 ± 8.4
62.0 ± 7.1
Males ()
294 (53.5)
345 (52.3)
48 (53.3)
246 (53.5)
24 (57.1)
24 (50.0)
30 (60.0)
18 (45.0)
Clinics
BMI (kg/m2)
28.7 ± 4.5
29.4 ± 4.9*
28.3 ± 4.0
28.8 ± 4.6
28.0 ± 3.3
28.6 ± 4.5
28.4 ± 4.0
28.1 ± 4.0
Diabetes duration (yrs)
7.9 ± 6.6
7.4 ± 6.5
10.5 ± 7.2
7.4 ± 6.3°°°
11.2 ± 7.5
9.9 ± 7.1
10.9 ± 7.0
10.1 ± 7.6
Smokers
Never
323 (58.7)
377 (57.2)
58 (64.4)
265 (57.6)
24 (57.1)
34 (70.8)
31 (62.0)
27 (67.5)
Former
169 (30.7)
194 (29.4)
24 (26.7)
145 (31.5)
14 (33.3)
10 (20.8)
15 (30.0)
9 (22.5)
Current
58 (10.5)
88 (13.3)
8 (8.9)
50 (10.9)
4 (9.5)
4 (8.3)
4 (8.0)
4 (10.0)
Laboratory
HbA1c (%)
5.9 ± 1.5
5.7 ± 1.3**
6.5 ± 1.5
5.8 ± 1.4°°°
6.6 ± 1.4
6.5 ± 1.7
6.6 ± 1.7
6.4 ± 1.2
Systolic BP (mm Hg)
151.6 ± 14.3
149.3 ± 12.9*
158.4±16.5
150.3 ± 13.5°°°
161.2 ± 15.3
155.9±17.2
154.3±15.2
189.0 ± 55.6
Diastolic BP (mm Hg)
88.8 ± 8.3
86.4 ± 6.9***
90.7 ± 8.2
88.4 ± 8.3°
92.4 ± 7.9
89.1±8.3
89.9±8.5
91.6 ± 7.9
Albuminuria (g/min)
6.8 ± 4.5
7.0 ± 4.6
8.1 ± 5.1
6.6 ± 4.4°°
8.0 ± 5.0
8.2 ± 5.2
8.3 ± 5.4
7.8 ± 4.6
Ser. creatinine (mg/dL)
0.9 ± 0.2
0.9 ± 0.2
0.9 ± 0.2
0.9 ± 0.2
0.9 ± 0.2
0.9 ± 0.1
0.9 ± 0.1
0.9 ± 0.2
Triglycerides (mg/dL)
143.5 ± 73.2
151.7 ± 83.4
146.3 ± 75.0
142.9 ± 72.9
146.7 ± 64.9
145.9 ± 83.6
139.7 ± 80.1
154.4 ± 68.2
Tot. Cholesterol (mg/dL)
212.0 36.5
208.5 ± 35.1
213.1 ± 40.5
211.8 ± 35.7
207.7 ± 31.2
217.8 ± 46.9
209.4 ± 37.3
217.7 ± 44.1
Data are mean ± SD or numbers and percentages (in brackets).
*
, **, *** versus Fundoscopy YES; °, °°, °°° versus Retinopathy YES; ^ versus ndCCB YES.