Review Article
Human Genetics of Diabetic Retinopathy: Current Perspectives
Table 2
Potential chromosomal regions linked to DR (LOD scores 1).
| Chromosome | Definition of DR | Population | LOD score | Nearest genetic markers | Reference |
| 1p36 | Retinopathy score in worst eye | Pima Indians | 3.1 | D1S3669 | [50] |
| 1p36 | Any DR | Mexican Americans | 1.24 | GGAT2A07 | [49] |
| 2q37 | Severe NPDR/PDR | Mexican Americans | 1.11 | AFM112yd4 | [49] |
| 3p26 | Severe NPDR/PDR | Mexican Americans | 1.29 | GATA22G12 | [49] |
| 3q12 | Severe NPDR/PDR | Mexican Americans | 1.40 | GATA68D03 | [49] |
| 3q12 | Any DR | Mexican Americans | 2.41 | GATA68D03 | [49] |
| 3q26 | Presence of at least one microaneruysm, hemorrahage or proliferative DR | Pima Indians | 1.36 | D3S3053, D3S2427 | [48] |
| 7p15 | Any DR | Mexican Americans | 1.02 | GATA41G07 | [49] |
| 9q21 | Presence of at least one microaneruysm, hemorrhage or proliferative DR | Pima Indians | 1.46 | D9S1120, D9S910 | [48] |
| 12p13 | Any DR | Mexican Americans | 2.47 | GATA49D12 | [49] |
| 12q23 | Severe NPDR/PDR | Mexican Americans | 1.03 | GATA85A04 | [49] |
| 15q25 | Any DR | Mexican Americans | 1.07 | ATA28G05 | [49] |
| 15q26 | Any DR | Mexican Americans | 1.16 | GATA22F01 | [49] |
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