Lacrimal Gland Involvement in Lymphomatoid Granulomatosis and Review of the Literature

Table 1

Lymphomatoid granulomatosis: clinical data.

Study	Age/Sex	Ocular manifestations	Onset	Extraocular manifestations	LYG established by biopsy	Initial presentation	Treatment	Follow up	Outcome
Leibow et al. [1]	33/M	Periorbital swelling	Acute	Sialadenitis		Sialadenitis and peri orbital swelling		1 1/2 months	D
	8 1/2/F	Ptosis,bilateral nystagmus,pale optic disc	Acute (2weeks)	CNS involvement	Wedge biopsy of lung	Systemic sym ptoms, ocular and CNS	Prednisolone	3 years	A
Shank et al. [2]	62/F	Supra orbital swelling	Acute (4 weeks)	lymph nodes, lung, CML	Open lung biopsy	Erythema nodosum	Radiotherapy, prednisolone, vincristine, cyclophosphamide	1 year	D
Katzenstein et al. [3]	NA	Atypical lyphoma of eyelids	NA	NA	NA	NA
	NA	Uveitis	NA	NA	NA	NA
Sordillo et al. [4]	62/M	Unilateral proptosis, lacrimal gland, conjunctival involvement	NA	Adenopathy pulmonary	Lymph node, lung	proptosis	Radiotherapy prednisolone, chemotherapy	4 years	A
	60/F	Orbital mass, choroidal infilt, CRVO	NA	Adenopathy, fever, pulmonary	Lung	Lymphadenopathy	Radiothaerpy, prednisolone, vincristine, cyclophosphamide	2 years	D
Fauci et al. [5]	NA		NA	NA	NA
	NA		NA	NA	NA
Saraux et al. [6]	35/F	Retinal arteritis, ptosis mydriasis	NA		Open lung biopsy	Rhinopharyngitis, pneumenia	Corticosteroids, cyclophosphamide, plasmapheresis	6 months	D
Tse et al. [7]	29/M	Bilateral peripheral retinal vasculitis and uveitis, decreased lacrimation	Chronic (3 months)	Pulmonary, cerebellar	open lung biopsy	rhinorrhea, dry cough, malaise	Prednisolone, radiotherapy	6 months	D
Chung YM et al. [8]	62/F	Ulcerative conjunctival nodule	NA		Lung biopsy			NA
Kinyoun et al. [9]	56/M	Inflammation of choriocapillaris	Chronic (6 months)	Pulmonary	Open lung biosy	productive cough	Corticosteroids, cyclophosphamide	12 years	A
Font et al. [10]	62/M	Eyelid and eyebrow involvement	Chronic (4 months)	Skin, pulmonary, adenopathy	Skin biopsy from eyebrow	skin lesions	Antibiotics, chemotherapy	3 years	D
McKay et al. [11]	60/F	Retrobulbar optic nerve infarction, Scleritis, ? Orbital infiltration	Acute		Nasal mucosa, sclera	presented with bilateral red eye	Radiotherapy, steroid	2 years	A
Pearson ADJ et al. [12]	13/M	Bilateral choroidal infiltration, diplopia sec to CN inv	NA	Pulmonary	Open lung biopsy	respiratory failure	Vincristine, cyclophosphamide, prednisolone	6 years	A
Haider. [13]	31/M	Tonic pupil	Acute (3 weeks)	GIT, skin	Skin	abdominal pain		NA	A
Moertel et al. [14]	7/F	Tonic pupil	NA	ALL, cerebral nodule, pulmonary	Lung biopsy	Lymphadenopathy, splenomegaly, pulmonary Infiltrates	Chemotherapy, dexamethasone	7 years	A
Forman et al. [14]	41/F	Unilateral optic neuropathy	Acute (1 week)	Pulmonary	Lung biopsy	monoocular visual loss		2 months	D
Head et al. [15]	54/M	Conjunctiavl growth	Sub acute Several wks	NA	Open lung biopsy	pulmonary	Radiotherapy to orbit	NA	A
Cameron and Cackett et al. [16]	39/M	Bilateral exudative retinal detachment	Acute (3 days)	Pulmonary, skin	Skin	cough, dyspnoea skin rash	Prednisolone	2 years	A
Pradeep et al.	75/F	Unilateral dacryoadenitis	Acute (2 weeks)	Pulmonary	Transbronchial biopsy	dacryoadenitis	Prednisolone and cyclophosphamide	6 months	D

F: female, M: male; NA-not available; CNS- central nervous system; GIT-gastrointestinal tract; ALL: Acute lymphocytic leukemia; CML- chronic myeloid leukemia; A: alive at the end of follow up period; D dead at the end of follow up period.