ERK5 Contributes to VEGF Alteration in Diabetic Retinopathy
ERK5 siRNA transfection reduced basal (5 mmol/l, LG) and glucose induced (25 mmol/l, HG) mRNA expression of ERK5 (a), MEF2C (b), KLF2 (c) in endothelial cells after 24 hrs of HG treatment. On the other hand, such transfection augmented VEGF mRNA expression (d). [Data are expressed as a ratio to -actin, normalized to controls, : significantly different from control siRNA in LG, : significant difference from control siRNA in HG, /group].
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