Leber's Hereditary Optic Neuropathy-Gene Therapy: From Benchtop to Bedside

Figure 1

Fundus photographs of a patient with acute LHON revealed swelling of the right (a) and left (b) optic nerve heads. The arrow indicates the characteristic peripapillary telangiectasia. Automated visual fields showed central scotomas in the left (c) and right (d) eyes. OCT confirmed and quantitated the swelling of the retinal nerve fiber layer (e). Pattern electroretinograms illustrated a decline in ganglion cell function occurred during the acute stages of LHON and before structural evidence of RGC loss (f).