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Journal of Ophthalmology
Volume 2011, Article ID 405724, 8 pages
Clinical Study

One-Year Outcomes Using Ranibizumab for Neovascular Age-Related Macular Degeneration: Results of a Prospective and Retrospective Observational Multicentre Study

1St. Erik's Eye Hospital, Karolinska Institutet, Polhemsgatan 50, 11282 Stockholm, Sweden
2Department of Ophthalmology, Lund University Hospital, 22185 Lund, Sweden
3Department of Ophthalmology, Helsingborg Hospital, 25187 Helsingborg, Sweden
4Department of Ophthalmology, Ryhov Hospital, 55185 Jönköping, Sweden
5Department of Ophthalmology, Södersjukhuset, 11883 Stockholm, Sweden
6Department of Ophthalmology, Örebro University Hospital, 70185 Örebro, Sweden
7Medical Department, Novartis Sweden AB, 18311 Täby, Sweden

Received 3 August 2011; Accepted 7 September 2011

Academic Editor: G. L. Spaeth

Copyright © 2011 Lars Hjelmqvist et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The Swedish Lucentis Quality Registry is a 12-month, open-label, observational, prospective, and retrospective study of ranibizumab administration for wet AMD. Visual acuity (VA) was measured with Snellen or ETDRS chart in 370 patients (66.8% women; age range 46–93 years). In total, a mean of injections per patient (range 1–10) was given to month 12. Mean VA score was letters before treatment, after 3 injections ( letters from baseline), and at 12 months (). VA score from baseline to month 12 was stable in 74.4% of patients, improved by 15 letters/3 lines or more in 14.7%, and decreased by 15 letters/3 lines in 10.9% of patients. With a mean of 4.7 ranibizumab injections per patient per year, mean VA was stabilised but not increased. To maintain the initial gain seen after the first three injections, an average of additional injections does not appear to be adequate.