Retrobulbar Hemodynamic Effects of Nipradilol in Normal and Normal-Tension Glaucoma Eyes
Table 2
Results of color Doppler imaging in normal volunteers.
Parameter
Nipradilo1
Placebo
Before
2 hrs ()
1 week ()
Before
2 hrs ()
1 week ()
Ophthalmic artery
PSV (cm/sec)
35.8 ± 8.4
31.8 ± 8.6 (0.0044)*
34.8 ± 8.6 (0.4769)
32.3 ± 10.8
31.8 ± 8.5 (0.6379)
31.6 ± 10.1 (0.5303)
EDV (cm/sec)
8.03 ± 2.40
7.52 ± 2.55 (0.4236)
8.76 ± 2.69 (0.0969)
8.17 ± 3.95
7.79 ± 2.13 (0.8753)
8.30 ± 2.89 (0.9063)
Resistance index
0.776 ± 0.035
0.764 ± 0.046 (0.2858)
0.749 ± 0.033 (0.0329*)
0.753 ± 0.065
0.753 ± 0.037 (0.7836)
0.738 ± 0.036 (0.3078)
Central retinal artery
PSV (cm/sec)
11.3 ± 3.1
11.4 ± 2.4 (0.9999)
12.0 ± 2.5 (0.1095)
11.9 ± 2.4
12.4 ± 2.2 (0.3739)
12.6 ± 2.4 (0.1823)
EDV (cm/sec)
4.18 ± 1.06
4.28 ± 0.91 (0.5937)
4.67 ± 0.92 (0.0409*)
4.53 ± 1.27
4.38 ± 1.03 (0.8240)
4.73 ± 0.94 (0.8589)
Resistance index
0.627 ± 0.038
0.622 ± 0.051 (0.4145)
0.606 ± 0.058 (0.1414)
0.623 ± 0.052
0.646 ± 0.059 (0.2662)
0.622 ± 0.057 (0.9999)
NPCA
PSV (cm/sec)
8.13 ± 1.85
8.36 ± 1.60 (0.4769)
8.02 ± 1.46 (0.8589)
9.43 ± 1.69
9.79 ± 1.22 (0.4243)
9.08 ± 0.89 (0.3743)
EDV (cm/sec)
3.43 ± 1.10
3.53 ± 0.78 (0.6833)
3.33 ± 0.85 (0.8588)
3.73 ± 0.81
4.06 ± 0.53 (0.2408)
3.66 ± 0.57 (0.5746)
Resistance index
0.584 ± 0.059
0.579 ± 0.041 (0.4496)
0.584 ± 0.067 (0.9999)
0.605 ± 0.051
0.582 ± 0.056 (0.2477)
0.596 ± 0.054 (0.3863)
TPCA
PSV (cm/sec)
10.2 ± 2.8
10.0 ± 3.1 (0.7895)
10.6 ± 2.9 (0.5337)
11.3 ± 3.0
11.0 ± 3.1 (0.7213)
10.9 ± 2.3 (0.2475)
EDV (cm/sec)
3.95 ± 1.27
4.25 ± 1.45 (0.0365)*
4.36 ± 1.68 (0.4236)
4.53 ± 1.36
4.72 ± 1.74 (0.4496)
4.44 ± 1.35 (0.2662)
Resistance index
0.614 ± 0.060
0.578 ± 0.057 (0.0164)*
0.600 ± 0.065 (0.2477)
0.597 ± 0.050
0.584 ± 0.043 (0.3739)
0.592 ± 0.074 (0.9292)
Values are presented as mean ± standard deviation. PSV: peak systolic velocity, EDV: end-diastolic velocity, NPCA: nasal short posterior ciliary artery, TPCA: temporal short posterior ciliary artery. Wilcoxon signed-rank sum test. .
