Pilot Study of the Delivery of Microcollimated Pars Plana External Beam Radiation in Porcine Eyes: 270-Day Analysis
Representative OCT montage of a 24 Gy and a 90 Gy animal, demonstrating dose-dependent treatment effect at day 270. In the 24 Gy swine, no obvious defects were seen with regard to retinal thinning or RPE hyperreflectivity. In 90 Gy animal, there is a dose-dependent decrease in retinal thickness and an increase in the RPE hyperreflectivity indicating significant retinal scarring. No findings were noted at 0 or 16 Gy, and progressively worsening retinal injury was seen at the 42, 60, and 90 Gy doses.