Visual Performance in Patients with Neovascular Age-Related Macular Degeneration Undergoing Treatment with Intravitreal Ranibizumab
Table 1
Psychophysical data for study eyes in the entire study group and Subgroup A, between baseline and exit study visits.
Variable
Entire group
Subgroup A
Baseline
exit
P value
Baseline
exit
P value
mean (±sd)
mean (±sd)
mean (±sd)
mean (±sd)
CDVA
88 (9)
89 (10)
0.480
89 (12)
91 (13)
0.387
logRAD
0.33 (0.20)
0.28 (0.22)
0.032
*
0.24 (0.18)
0.19 (0.19)
0.139
Reading speed
85 (28)
103 (46)
0.019
*
85 (26)
118 (56)
0.037
*
Mean reading speed
136 (36)
146 (42)
0.005
**
148 (28)
166 (36)
0.005
**
CS (mesopic)†
Frequency (cpd)
1.5
19.47 (10.1)
30.22 (21.00)
0.003
**
20.30 (12.15)
39.43 (26.12)
0.008
**
3
28.93 (19.72)
42.02 (34.04)
0.004
**
32.47 (24.01)
53.13 (33.87)
0.036
*
6
11.26 (9.78)
15.91 (17.32)
0.002
**
10.43 (9.04)
10.14 (6.35)
0.070
12
4.09 (1.17)
4.88 (2.27)
<0.005
**
3.80 (0.77)
6.27 (3.35)
0.001
**
18
1.98 (0.15)
2.37 (1.25)
<0.005
**
1.93 (0.26)
3.07 (1.98)
0.001
**
CS (photopic)†
Frequency (cpd)
1.5
21.99 (13.83)
27.27 (18.91)
0.082
19.51 (11.11)
23.32 (14.91)
0.347
3
35.05 (23.68)
47.63 (30.12)
0.005**
40.00 (30.72)
61.07 (32.54)
0.020
*
6
19.56 (19.28)
28.44 (30.98)
0.001
**
16.14 (16.75)
18.43 (15.90)
0.221
12
5.72 (4.00)
10.16 (15.29)
<0.005
**
7.40 (6.53)
19.47 (23.08)
0.025
*
18
2.49 (2.59)
3.58 (4.01)
<0.005
**
2.33 (1.59)
6.53 (5.82)
0.016
*
GD (mesopic)†
Frequency (cpd)
1.5
11.10 (7.88)
18.76 (15.03)
0.002
**
12.40 (9.79)
27.87 (17.80)
0.019
*
3
16.47 (12.63)
29.28 (23.67)
<0.005
**
17.93 (14.80)
42.13 (30.51)
0.001
**
6
7.51 (6.02)
11.49 (11.71)
<0.005
**
6.00 (0.00)
7.00 (2.58)
0.134
12
4.02 (0.77)
4.70 (2.89)
<0.005
**
3.80 (0.77)
6.00 (4.72)
0.001
**
18
1.98 (0.15)
2.09 (0.43)
<0.005
**
1.93 (0.26)
2.27 (0.70)
<0.005
**
GD (photopic)†
Frequency (cpd)
1.5
19.94 (12.38)
24.50 (14.79)
0.090
19.02 (13.31)
21.54 (13.27)
0.377
3
35.16 (25.82)
47.33 (33.20)
<0.005
**
43.13 (30.86)
67.67 (39.65)
0.039
*
6
19.04 (19.46)
28.42 (31.20)
0.001
**
15.25 (14.22)
18.50 (19.24)
0.069
12
5.84 (5.96)
7.86 (9.21)
<0.005
**
7.53 (9.21)
13.80 (13.66)
0.022
*
18
2.40 (1.68)
3.63 (4.05)
<0.005
**
2.73 (2.63)
6.67 (5.83)
0.021
*
Mean ROS (dB)
Fixation
8.56 (5.91)
10.20 (5.71)
0.026
*
8.36 (7.32)
11.64 (6.72)
0.056
Central 5°
9.63 (4.83)
11.18 (4.48)
0.003
**
9.27 (6.46)
12.34 (5.17)
0.013
*
Central 16°
11.03 (4.49)
12.11 (4.00)
0.005
**
10.32 (5.51)
12.55 (4.42)
0.017
*
OCT
MFT (μm)
233 (59)
205 (40)
0.001
**
275 (64)
208 (25)
0.002
**
MFV (μm3)
0.18 (0.05)
0.16 (0.03)
<0.005
**
0.22 (0.05)
0.16 (0.02)
0.002
**
Abbreviations: reading speed (at best baseline LogRad value); wpm: words per minute; mean reading speed (for range of LogRad values); CS: contrast sensitivity; mesopic: under mesopic conditions; cpd: cycles per degree; photopic: under photopic conditions; GD: glare disability; ROS: retinotopic ocular sensitivity; dB: decibel; OCT: optical coherence tomography; MFT: mean foveal thickness; MFV: mean foveal volume; —: change was not significant. Note: The P values reported are for the paired test (or the corresponding nonparametric test when the data distribution was non-normal). Significant improvement at the 0.05 level (2 tailed). Significant improvement at the 0.01 level (2 tailed). †The statistical tests were based on log-transformed data.
