Table of Contents Author Guidelines Submit a Manuscript
Journal of Ophthalmology
Volume 2013, Article ID 315658, 8 pages
http://dx.doi.org/10.1155/2013/315658
Research Article

Uniform Suspension of the Clustered Triamcinolone Acetonide Particle

1Department of Ophthalmology, Mie University, School of Medicine, 2-174 Edobashi, Mie, Tsu 514-8507, Japan
2Department of Ophthalmology, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi. 470-1192, Japan

Received 3 November 2012; Accepted 30 December 2012

Academic Editor: Edward Manche

Copyright © 2013 Masahiko Sugimoto et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose. MaQaid (MaQ) is a new triamcinolone acetonide commercialised in Japan to visualize the vitreous. Because MaQ is preservative-free, it has a lower risk of ocular toxicities. However, since MaQ is only available as a powder, it needs suspenssion. Suspension does not always result uniformally, which causes poor visibility. This study reports a new MaQ suspension for better visibility. Methods. After medium addition to a MaQ vial, various methods were used. These included the use of (1) vortex mixer, (2) two syringes and a three-way stopcock, and (3) ultrasonic washer. We calculated suspended MaQ concentration ( ). To evaluate the reproducibility, we estimated the coefficient of variance (CV, ). We used this MaQ for pig eyes, and vitreous visualization was simulated. Subsequently, we used this MaQ suspension for humans. Results. MaQ suspensions were sucessfull, and the concentrations of single particles increased significantly ( ). The CV was 36.1% for the routine method and 9.03% ffor the new method. Administration of a suspended MaQ made it possible to clearly visualize the vitreous in both pig and human eyes. Conclusions. We devised new techniques for uniformal MaQ suspension. These new methods can compensate for the MaQ disadvantages and ensure a safety surgery.