Clinical Study

Grading of Age-Related Macular Degeneration: Comparison between Color Fundus Photography, Fluorescein Angiography, and Spectral Domain Optical Coherence Tomography

Table 1

Parameters evaluated as signs for AMD, CNV, and CNV activity.

Color fundus photographyFluorescein angiographySDOCT

AMD Presence of ≥10 small hard drusen and pigmentary changes or ≥1 intermediate or large drusen inside the 6 mm ETDRS grid

CNVFibrosis, fibrovascular tissue, or fibrin either subretinal or subRPE (not related to any other retinal vascular disease but CNV)Classic or occult CNV or staining scarSubretinal hyperreflective material or PED other than single drusen

CNV
activity
Fluid or hemorrhage related to CNVClassic or occult CNV leakageDiffuse or cystoid intraretinal fluid or subretinal fluid

AMD: age-related macular degeneration; CNV: choroidal neovascularization; FA: fluorescein angiography; SDOCT: spectral-domain optical coherence tomography; RPE: retinal pigment epithelium; and PED: pigment epithelial detachment.