Systems Biology Profiling of AMD on the Basis of Gene Expression

Table 1

Description of AMD phenotypic subtypes according to Newman et al. [1]. Abbreviated names in the first column are used in labeling the cladograms’ legends in Figures 1 and 2.

AMD phenotype	Alternative name	Description
MD1	Pre-AMD	Hard macular drusen (<63 μm) only
MD2	Subclinical; pre-AMD	Soft, distinct macular drusen (>63 μm); Macular pigmentary irregularities without soft drusen
Dry AMD	Dry AMD; (non-GA)	Soft, indistinct (>125 μm) or reticular macular drusen; Soft distinct macular drusen (>63 μm) with pigmentary changes; Soft indistinct macular drusen with pigmentary changes
GA	Geographic atrophy	Sharply demarcated area of apparent absence of the RPE (>175 μm) involving central macular region
CNV	Wet AMD	Subretinal choroidal neovascularization
GA/CNV		Geographic atrophy with choroidal neovascularization