Journal of Ophthalmology / 2013 / Article / Tab 3

Research Article

Systems Biology Profiling of AMD on the Basis of Gene Expression

Table 3

Affected retinal signaling pathways at different locations of cladogram in Figure 1. Sample identification follows

First node
Shared by all retinal specimens
(Sample GSM738713)
Lower part of the cladogram
Specimen: RetDRY98
(Sample GSM738705)
Middle part of the cladogram
Specimen: RetDRY70
(Sample GSM738677)
Upper part of the cladogram

(1) Apoptosis
(2) Cell cycle
(3) Cytoskeleton
(4) Differentiation
(5) Growth
(6) Insulin metabolism
(1) Apoptosis
(2) Cell cycle
(3) Development
(4) Growth
(5) Neurotransmission
(6) Transcription activation
(7) Tumor suppression
(1) Cytokine receptor degradation signaling
(2) Cytosolic calcium ion concentration elevation (through IP3 receptor) (GPCR signaling (G alpha q))
(3) EGFR1
(4) ERK cascade GPCR signaling (G alpha s, PKA, and ERK)
(5) Protein binding
(6) Proteolysis
(1) Amyloid metabolism
(2) Apoptosis
(3) Cell cycle
(4) Cytoskeleton
(5) Immunoregulation
(6) Inflammation
(7) Lipid metabolism
(8) Retinoid metabolism
(9) Ribosomal proteins
(10) Telomere metabolism

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