Table of Contents Author Guidelines Submit a Manuscript
Journal of Ophthalmology
Volume 2013, Article ID 821460, 7 pages
http://dx.doi.org/10.1155/2013/821460
Clinical Study

The Structure-Function Relationship between Macular Morphology and Visual Function Analyzed by Optical Coherence Tomography in Retinitis Pigmentosa

Department of Ophthalmology, Seoul National University College of Medicine, 103 Daehakro, Jongnogu, Seoul 110-799, Republic of Korea

Received 2 May 2013; Revised 28 September 2013; Accepted 12 October 2013

Academic Editor: Andrew G. Lee

Copyright © 2013 Chang Ki Yoon and Hyeong Gon Yu. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose. To evaluate the relationship between macular microstructures and visual function in retinitis pigmentosa (RP). Method. Fourier domain optical coherence tomography (FD-OCT) and Goldmann perimetry were used to examine 100 eyes of 100 RP patients. The preserved photoreceptor outer segment (PROS) length was measured at the horizontal and vertical high definition line scans. The PROS area was calculated from slab image and line scans simultaneously. The visual field area (VFA) was quantified. Each retinal thickness was measured: inner retina (IRT), outer retina (ORT), subfoveal choroidal thickness (SFCT), and central retinal thickness (CRT). Results. The PROS area values acquired differently were consistent. The VFA was related significantly to the CRT, ORT, PROS length (vertical and horizontal), and PROS area (line scan and slab image). Visual acuity was correlated with the CRT, ORT, IRT, PROS length (horizontal and vertical), and PROS area (line scan and slab image) significantly. Multiple linear regression analysis revealed that the PROS horizontal length and ORT were related to the VFA and visual acuity, respectively. Conclusion. Among the macular microstructures, the PROS horizontal length and the ORT were most correlated with VFA and visual acuity, respectively. However, SFCT is not related to visual function.