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Journal of Ophthalmology
Volume 2014 (2014), Article ID 178132, 7 pages
Clinical Study

Treatment of Corneal Neovascularization Using Anti-VEGF Bevacizumab

Ophthalmology Department, 3rd Medical Faculty of Charles University and University Hospital Kralovske Vinohrady, Srobarova 50, 10034 Prague, Czech Republic

Received 14 December 2013; Revised 18 February 2014; Accepted 19 February 2014; Published 23 March 2014

Academic Editor: Francisco Javier Romero

Copyright © 2014 Deli Krizova et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. To evaluate antiangiogenic effect of local use of bevacizumab (anti-VEGF antibody) in patients with corneal neovascularization. Methods. Patients were divided into two groups. All patients suffered from some form of corneal neovascularization (NV). Patients in group A received 0.2–0.5 mL of bevacizumab solution subconjunctivally (concentration 25 mg/mL) in a single dose. Group A included 28 eyes from 27. Patients in group B applied bevacizumab eye drops twice daily (concentration 2.5 mg/mL) for two weeks. Group B included 38 eyes from 35 patients. We evaluated the number of corneal segments affected by NV, CDVA, and the incidence of complications and subjective complaints related to the treatment. The minimum follow-up period was six months. Results. By the 6-month follow-up, in group A the percentage reduction of the affected peripheral segments was 21.6% and of the central segments was 9.6%; in group B the percentage reduction of the central segments was 22.7% and of the central segments was 38.04%. In both groups we noticed a statistically significant reduction in the extent of NV. Conclusion. The use of bevacizumab seems to be an effective and safe method in the treatment of corneal neovascularization, either in the subconjunctival or topical application form.