Association of Maternal Age to Development and Progression of Retinopathy of Prematurity in Infants of Gestational Age under 33 Weeks

Table 1

Univariate analyses of risk factors for developing any stage of ROP in gestational age <33 weeks infants.

Variable	Without ROP (𝑛=98)	Any stage of ROP (𝑛=84)	𝑃 value	Odds ratio	95% CI
Gestational age (weeks)^†	31.1 (29.3–32.0)	26.7 (25.5–28.3)	<𝟎.𝟎𝟎𝟏^∗	0.474	0.386–0.584
Birth weight (g)^†	1356 (1057–1635)	761 (596–919)	<𝟎.𝟎𝟎𝟏^∗	0.995	0.993–0.996
Maternal age (years)^†	33 (30–37)	31 (28–35)	𝟎.𝟎𝟎𝟗^∗	0.924	0.869–0.984
SGA (𝑛, %)	26 (27)	36 (43)	𝟎.𝟎𝟐𝟏^∗	2.077	1.114–3.872
Apgar score; 1 min^†	6 (4–8)	3 (1–6)	<𝟎.𝟎𝟎𝟏^∗	0.735	0.647–0.834
Apgar score; 5 min^†	8 (6–9)	6 (4–8)	<𝟎.𝟎𝟎𝟏^∗	0.651	0.548–0.774
Multiple birth (𝑛, %)	28 (29)	20 (24)	0.467	0.781	0.401–1.521
Gender; Male (𝑛, %)	56 (57)	39 (46)	0.149	0.650	0.362–1.168
Pulmonary surfactant (𝑛, %)	32 (33)	54 (64)	<𝟐𝟐𝟎.𝟎𝟎𝟏^∗	3.713	2.008–6.862

CI: confidence interval; ROP: retinopathy of prematurity; SGA: small for gestational age.
^∗𝑃<0.05.
†Median (interquartile range).